Elemene Emulsion Injection Administration Reduces Neuropathic Pain by Inhibiting Astrocytic NDRG2 Expression within Spinal Dorsal Horn
| Autor: | Li-tian Ma, Jie Li, Jin Zheng, Yang Bai, Yu Qiao, Yang Liu |
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| Rok vydání: | 2021 |
| Předmět: |
Spinal Cord Dorsal Horn
medicine.medical_specialty SNi 0211 other engineering and technologies Nerve Tissue Proteins 02 engineering and technology 030226 pharmacology & pharmacy Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Downregulation and upregulation Internal medicine 021105 building & construction medicine Animals Pharmacology (medical) Glial fibrillary acidic protein biology business.industry General Medicine Nerve injury Rats Disease Models Animal medicine.anatomical_structure Endocrinology Spinal Cord Complementary and alternative medicine chemistry Hyperalgesia Astrocytes Neuropathic pain biology.protein Neuralgia Emulsions medicine.symptom business Elemene Sesquiterpenes Immunostaining Astrocyte |
| Zdroj: | Chinese Journal of Integrative Medicine. 27:912-918 |
| ISSN: | 1993-0402 1672-0415 |
| Popis: | OBJECTIVE To investigate the mechanisms underlying elemene-induced analgesia in rats with spared nerve injury (SNI). METHODS Sixty-five rats were equally divided into 5 groups using a random number table: naive group, sham group, SNI group, SNI + elemene (40 mg·kg-1·d-1) group and naive + elemene (40 mg·kg-1·d-1) group. An SNI rat model was established and the intervention were given respectively for 14 consecutive days. Von Frey filament tests and elevated plus-maze (EPM) tests were used to evaluate the effect of elemene on the mechanical threshold and anxiety, respectively. Immunoblotting and immunostaining were used to measure the expression of glial fibrillary acidic protein (GFAP) and NMYC downstream-regulated gene 2 (NDRG2) within the lumbar spinal dorsal horn (SDH). RESULTS The SNI rat model exhibited a significant decrease in paw withdrawal threshold and exploratory behaviour in the EPM (P |
| Databáze: | OpenAIRE |
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