The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment

Autor: Caroline Pham, Noelia Muñoz-Martín, Elisabeth M. Lodder
Rok vydání: 2021
Předmět:
0301 basic medicine
Heart Diseases
Basic science
QH301-705.5
Cardiomyopathy
Conduction disease
Ischemia
Disease
Review
Supraventricular arrhythmias
030204 cardiovascular system & hematology
Protein Serine-Threonine Kinases
Bioinformatics
Catalysis
Muscle hypertrophy
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Regeneration
Myocardial infarction
Molecular Targeted Therapy
Physical and Theoretical Chemistry
Biology (General)
Phosphorylation
Molecular Biology
QD1-999
Spectroscopy
Supraventricular arrhythmia
business.industry
Organic Chemistry
TNNI3K
General Medicine
Hypertrophy
medicine.disease
Computer Science Applications
Chemistry
Disease Models
Animal
030104 developmental biology
cardiovascular system
Cardiac regeneration
business
Reperfusion injury
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 6422, p 6422 (2021)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: In the two decades since the discovery of TNNI3K it has been implicated in multiple cardiac phenotypes and physiological processes. TNNI3K is an understudied kinase, which is mainly expressed in the heart. Human genetic variants in TNNI3K are associated with supraventricular arrhythmias, conduction disease, and cardiomyopathy. Furthermore, studies in mice implicate the gene in cardiac hypertrophy, cardiac regeneration, and recovery after ischemia/reperfusion injury. Several new papers on TNNI3K have been published since the last overview, broadening the clinical perspective of TNNI3K variants and our understanding of the underlying molecular biology. We here provide an overview of the role of TNNI3K in cardiomyopathy and arrhythmia covering both a clinical perspective and basic science advancements. In addition, we review the potential of TNNI3K as a target for clinical treatments in different cardiac diseases.
Databáze: OpenAIRE
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