A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial
Autor: | Ingegerd Söderström, Andreas Stomby, Maria Waling, Jon Hauksson, Mats Ryberg, Andreas Isaksson, Tommy Olsson, Julia Otten, Michael Svensson |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Blood Glucose Male Weight loss Time Factors Endocrinology Diabetes and Metabolism Type 2 diabetes medicine.disease_cause Intramyocellular fat law.invention 0302 clinical medicine Randomized controlled trial law Single-Blind Method Adiposity Middle Aged Insulin sensitivity Combined Modality Therapy Exercise Therapy medicine.anatomical_structure Treatment Outcome Adipose Tissue Liver Diet Paleolithic Endokrinologi och diabetes Female Adult medicine.medical_specialty 030209 endocrinology & metabolism Endocrinology and Diabetes Article Hyperinsulinaemic–euglycaemic clamp 03 medical and health sciences Paleolithic diet Internal medicine Internal Medicine medicine Humans Liver fat Obesity Muscle Skeletal Exercise Aged Nutrition Sweden Proton magnetic resonance spectroscopy business.industry Skeletal muscle medicine.disease 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Hyperinsulinaemic-euglycaemic clamp Insulin Resistance business Deposition (chemistry) |
Zdroj: | Diabetologia |
ISSN: | 1432-0428 |
Popis: | Aims/hypothesis The aim of the study was to investigate ectopic fat deposition and insulin sensitivity, in a parallel single-blinded randomised controlled trial, comparing Paleolithic diet alone with the combination of Paleolithic diet and exercise in individuals with type 2 diabetes. Methods Thirty-two individuals with type 2 diabetes with BMI 25–40 kg/m2 and 30–70 years of age followed a Paleolithic diet ad libitum for 12 weeks. In addition, study participants were randomised by computer program to either supervised combined exercise training (PD-EX group) or standard care exercise recommendations (PD group). Staff performing examinations and assessing outcomes were blinded to group assignment. Thirteen participants were analysed in each group: hepatic and peripheral insulin sensitivity were measured using the hyperinsulinaemic–euglycaemic clamp technique combined with [6,6-2H2]glucose infusion, and liver fat was assessed by proton magnetic resonance spectroscopy; both analyses were secondary endpoints. Intramyocellular lipid (IMCL) content was measured by magnetic resonance spectroscopy as a secondary analysis. All examinations were performed at Umeå University Hospital, Umeå, Sweden. Results Both study groups showed a median body weight loss of 7 kg. Fat mass decreased by 5.7 kg in the PD group and by 6.5 kg in the PD-EX group. Maximum oxygen uptake increased in the PD-EX group only. Liver fat showed a consistent reduction (74% decrease) in the PD group, while the response in the PD-EX group was heterogeneous (p |
Databáze: | OpenAIRE |
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