A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial

Autor: Ingegerd Söderström, Andreas Stomby, Maria Waling, Jon Hauksson, Mats Ryberg, Andreas Isaksson, Tommy Olsson, Julia Otten, Michael Svensson
Rok vydání: 2017
Předmět:
0301 basic medicine
Blood Glucose
Male
Weight loss
Time Factors
Endocrinology
Diabetes and Metabolism
Type 2 diabetes
medicine.disease_cause
Intramyocellular fat
law.invention
0302 clinical medicine
Randomized controlled trial
law
Single-Blind Method
Adiposity
Middle Aged
Insulin sensitivity
Combined Modality Therapy
Exercise Therapy
medicine.anatomical_structure
Treatment Outcome
Adipose Tissue
Liver
Diet
Paleolithic
Endokrinologi och diabetes
Female
Adult
medicine.medical_specialty
030209 endocrinology & metabolism
Endocrinology and Diabetes
Article
Hyperinsulinaemic–euglycaemic clamp
03 medical and health sciences
Paleolithic diet
Internal medicine
Internal Medicine
medicine
Humans
Liver fat
Obesity
Muscle
Skeletal
Exercise
Aged
Nutrition
Sweden
Proton magnetic resonance spectroscopy
business.industry
Skeletal muscle
medicine.disease
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
Hyperinsulinaemic-euglycaemic clamp
Insulin Resistance
business
Deposition (chemistry)
Zdroj: Diabetologia
ISSN: 1432-0428
Popis: Aims/hypothesis The aim of the study was to investigate ectopic fat deposition and insulin sensitivity, in a parallel single-blinded randomised controlled trial, comparing Paleolithic diet alone with the combination of Paleolithic diet and exercise in individuals with type 2 diabetes. Methods Thirty-two individuals with type 2 diabetes with BMI 25–40 kg/m2 and 30–70 years of age followed a Paleolithic diet ad libitum for 12 weeks. In addition, study participants were randomised by computer program to either supervised combined exercise training (PD-EX group) or standard care exercise recommendations (PD group). Staff performing examinations and assessing outcomes were blinded to group assignment. Thirteen participants were analysed in each group: hepatic and peripheral insulin sensitivity were measured using the hyperinsulinaemic–euglycaemic clamp technique combined with [6,6-2H2]glucose infusion, and liver fat was assessed by proton magnetic resonance spectroscopy; both analyses were secondary endpoints. Intramyocellular lipid (IMCL) content was measured by magnetic resonance spectroscopy as a secondary analysis. All examinations were performed at Umeå University Hospital, Umeå, Sweden. Results Both study groups showed a median body weight loss of 7 kg. Fat mass decreased by 5.7 kg in the PD group and by 6.5 kg in the PD-EX group. Maximum oxygen uptake increased in the PD-EX group only. Liver fat showed a consistent reduction (74% decrease) in the PD group, while the response in the PD-EX group was heterogeneous (p
Databáze: OpenAIRE
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