Association between insulin resistance and the magnetic resonance spectroscopy-determined marrow fat fraction in nondiabetic postmenopausal women
| Autor: | Xuefeng Li, Shixin Chang, Yilei Chen, Zheng Xu, Guanwu Li, Haiyang Lin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine medicine.medical_specialty Magnetic Resonance Spectroscopy General Mathematics 030209 endocrinology & metabolism 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Insulin resistance Bone Marrow Internal medicine Diabetes mellitus medicine Hyperinsulinemia Humans Aged Femoral neck Bone mineral Lumbar Vertebrae Anthropometry medicine.diagnostic_test business.industry Applied Mathematics Obstetrics and Gynecology Middle Aged medicine.disease 030104 developmental biology Endocrinology medicine.anatomical_structure Adipose Tissue Diabetes Mellitus Type 2 Homeostatic model assessment Female Insulin Resistance Menopause Lipid profile business Body mass index |
| Zdroj: | Menopause. 25:676-682 |
| ISSN: | 1530-0374 1072-3714 |
| DOI: | 10.1097/gme.0000000000001063 |
| Popis: | OBJECTIVE The clinical consequences of insulin resistance and hyperinsulinemia on marrow lipid remain elusive. We aimed to explore the effects of anthropometric and biochemical measures, that is, estimates of insulin resistance, on marrow lipid accumulation in nondiabetic postmenopausal women using magnetic resonance (MR) spectroscopy. METHODS The study participants were 91 nondiabetic postmenopausal women. Marrow fat fraction (FF) at the L3 vertebral body by single-voxel MR spectroscopy and bone mineral density (BMD) by dual-energy x-ray absorptiometry were measured. Their glucose and lipid metabolism were determined by biochemical analysis, and their insulin sensitivity was evaluated using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). RESULTS Adjusted for multiple covariates including age, years since menopause, body mass index, alcohol intake, tobacco use, physical activity, and serum lipid profile, the mean FF was significantly increased, and BMD at the lumbar spine, femoral neck, and total hip decreased as quartiles of HOMA-IR increased (P for trends |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|