Ascites volume at the time of primary debulking and overall survival of patients with advanced epithelial ovarian cancer
| Autor: | Ashley Haggerty, Lori Cory, Nawar A. Latif, Robert L. Giuntoli, Dimitrios Nasioudis, S.H. Kim, Maureen Byrne, Emily M. Ko |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Urology Carcinoma Ovarian Epithelial Disease-Free Survival Ascites Humans Medicine Stage (cooking) Aged Retrospective Studies Ovarian Neoplasms Chemotherapy business.industry Proportional hazards model Obstetrics and Gynecology Cancer Cytoreduction Surgical Procedures Middle Aged medicine.disease Debulking Log-rank test Oncology Female medicine.symptom business Ovarian cancer |
| Zdroj: | International Journal of Gynecologic Cancer. 31:1579-1583 |
| ISSN: | 1525-1438 1048-891X |
| Popis: | ObjectivesTo investigate the impact of malignant ascites volume on the outcomes of patients with advanced epithelial ovarian carcinoma who undergo primary debulking surgery.MethodsPatients diagnosed with stage III–IV epithelial ovarian carcinoma and bulky intra-abdominal (TIIIC) disease between 2010 and 2015, who underwent primary debulking surgery followed by multi-agent chemotherapy and known status of residual disease, were drawn from the National Cancer Database. Based on available information, the presence and volume of malignant ascites was categorized as absent, low (>980 mL) volume. Median overall survival was determined from Kaplan–Meier curves and compared with the log rank test. A multivariate Cox model was constructed to control for confounders.Results2493 patients were identified; 31.9% (n=795) had no ascites, 40.2% (n=1001) had low, and 28% (n=697) had high volume malignant ascites. Rate of complete gross resection was higher for patients with no ascites (65.9%) compared with those with low (35.6%) and high (23%) volume ascites (pConclusionsThe presence and volume of malignant ascites at the time of primary debulking surgery was associated with the likelihood of achieving a complete gross resection and worse overall survival. |
| Databáze: | OpenAIRE |
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