Ultrasensitive detection of hazardous reactive oxygen species using flexible organic transistors with polyphenol-embedded conjugated polymer sensing layers
| Autor: | Mohamed Fethi Diouani, Hwajeong Kim, Youngkyoo Kim, Chulyeon Lee, Meriam Haoues, Makram Essafi, Jaehoon Jeong |
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| Přispěvatelé: | Kyungpook National University [Daegu], Laboratoire de Transmission, Contrôle et Immunobiologie des Infections - Laboratory of Transmission, Control and Immunobiology of Infection (LR11IPT02), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université de Tunis El Manar (UTM), Laboratoire d’Epidémiologie et de Microbiologie Vétérinaire (LR11IPT03), This work was mainly supported by the international collaboration project between Korea and Tunisia (NRF_2012K1A3A1A09027883 and MESRS_TK32/2012). Y. Kim and H. Kim acknowledge further financial support from the Korean Government (NRF_2014R1A1A3051165, NRF_2016H1D5A1910319, NRF_2017M2A2A4A01071010, and Basic Science Research Program_2009-0093819). |
| Rok vydání: | 2018 |
| Předmět: |
Polyphenol
Environmental Engineering Transistors Electronic Rutin Health Toxicology and Mutagenesis Biosensing Techniques Thiophenes 02 engineering and technology Conjugated polymers Conjugated system 010402 general chemistry 01 natural sciences law.invention Matrix (chemical analysis) Mice chemistry.chemical_compound Superoxides law [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Animals Environmental Chemistry Waste Management and Disposal chemistry.chemical_classification Reactive oxygen species Organic field-effect transistor Superoxide Transistor Polyphenols Flexible organic transistors Polymer 021001 nanoscience & nanotechnology Pollution 0104 chemical sciences Hazardous superoxide level RAW 264.7 Cells chemistry Chemical engineering 0210 nano-technology |
| Zdroj: | Journal of Hazardous Materials Journal of Hazardous Materials, Elsevier, 2018, 355, pp.17--24. ⟨10.1016/j.jhazmat.2018.04.063⟩ |
| ISSN: | 0304-3894 1873-3336 |
| Popis: | International audience; Here we report that superoxide, one of the hazardous reactive oxygen species (ROS), can be quickly detected by flexible organic field-effect transistors (OFETs) with the polyphenol-embedded conjugated polymer micro-channels. Rutin, one of the abundant polyphenols found in a variety of plants, was employed as a sensing molecule and embedded in the poly(3-hexylthiophene) (P3HT) matrix. The rutin-embedded P3HT layers showed randomly distributed micro-domains, which became bigger as the rutin content increased. The best transistor performance was achieved at the rutin content of 10 wt%, while the OFETs exhibited proper and controllable transistor performances even in the phosphate buffer solutions. The sensing test revealed that the present OFET sensors could stably detect superoxide using very small amount (\textless10 μl) of samples at extremely low concentrations (500 pM), while they exhibited outstanding stability and durability upon repeated detection and storage-reuse tests. Finally, the present flexible OFET sensors could deliver confident sensing results for the detection of superoxide generated from the mouse RAW264.7 macrophages. |
| Databáze: | OpenAIRE |
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