Osmotic tension as a possible link between GABA(A) receptor activation and intracellular calcium elevation
| Autor: | Maria Elisa Forero, Joël Chavas, Isabel Llano, Thibault Collin, Alain Marty |
|---|---|
| Přispěvatelé: | Laboratoire de physiologie cérébrale (LPC - UMR 8118), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5), Université Paris Diderot - Paris 7 (UPD7) - Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Intracellular Fluid
Osmosis Cell Calcium in biology Membrane Potentials 0302 clinical medicine Cerebellum MESH: Animals MESH: Neuronal Plasticity Receptor MESH: Receptors GABA-A 0303 health sciences Neuronal Plasticity Muscimol GABAA receptor MESH: Intracellular Fluid General Neuroscience Depolarization MESH: Interneurons medicine.anatomical_structure MESH: Calcium GABAergic [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] medicine.medical_specialty MESH: Rats Neuroscience(all) Biology MESH: Calcium Signaling 03 medical and health sciences Organ Culture Techniques Interneurons MESH: GABA Agonists Internal medicine medicine Animals MESH: Membrane Potentials Calcium Signaling [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] GABA Agonists 030304 developmental biology MESH: Osmosis Repetitive stimulation Receptors GABA-A MESH: Organ Culture Techniques MESH: Cerebellum Rats Endocrinology nervous system Synaptic plasticity Biophysics Calcium 030217 neurology & neurosurgery MESH: Muscimol |
| Zdroj: | Neuron Neuron, Elsevier, 2004, 44 (4), pp.701-13. ⟨10.1016/j.neuron.2004.11.002⟩ Neuron, Elsevier, 2004, 44 (4), pp.701-13. 〈10.1016/j.neuron.2004.11.002〉 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2004.11.002⟩ |
| Popis: | International audience; Intracellular calcium concentration rises have been reported following activation of GABA(A) receptors in neonatal preparations and attributed to activation of voltage-dependent Ca(2+) channels. However, we show that, in cerebellar interneurons, GABA(A) agonists induce a somatodendritic Ca(2+) rise that persists at least until postnatal day 20 and is not mediated by depolarization-induced Ca(2+) entry. A local Ca(2+) elevation can likewise be elicited by repetitive stimulation of presynaptic GABAergic afferent fibers. We find that, following GABA(A) receptor activation, bicarbonate-induced Cl(-) entry leads to cell depolarization, Cl(-) accumulation, and osmotic tension. We propose that this tension induces the intracellular Ca(2+) rise as part of a regulatory volume decrease reaction. This mechanism introduces an unexpected link between activation of GABA(A) receptors and intracellular Ca(2+) elevation, which could contribute to activity-driven synaptic plasticity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|