Development and Cell Biology of the Blood-Brain Barrier
| Autor: | Chenghua Gu, Urs H. Langen, Swathi Ayloo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Central Nervous System
Central nervous system Biology Blood–brain barrier Basement Membrane Article Tight Junctions 03 medical and health sciences 0302 clinical medicine Leukocytes medicine Animals Homeostasis Humans Wnt Signaling Pathway Brain function 030304 developmental biology 0303 health sciences Brain Endothelial Cells Biological Transport Cell Biology Structure and function Cell biology medicine.anatomical_structure Blood-Brain Barrier Astrocytes cardiovascular system Neurovascular Coupling Pericytes Transcytosis 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Annu Rev Cell Dev Biol |
| ISSN: | 1530-8995 1081-0706 |
| Popis: | The vertebrate vasculature displays high organotypic specialization, with the structure and function of blood vessels catering to the specific needs of each tissue. A unique feature of the central nervous system (CNS) vasculature is the blood-brain barrier (BBB). The BBB regulates substance influx and efflux to maintain a homeostatic environment for proper brain function. Here, we review the development and cell biology of the BBB, focusing on the cellular and molecular regulation of barrier formation and the maintenance of the BBB through adulthood. We summarize unique features of CNS endothelial cells and highlight recent progress in and general principles of barrier regulation. Finally, we illustrate why a mechanistic understanding of the development and maintenance of the BBB could provide novel therapeutic opportunities for CNS drug delivery. |
| Databáze: | OpenAIRE |
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