Тhe role of the internal use of mineral water in the complex treatment of patients with chronic viral hepatitis C with concomitant non-alcoholic fatty liver disease

Autor: Anna Izha
Rok vydání: 2020
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 10, Iss 1, Pp 226-235 (2020)
ISSN: 2391-8306
DOI: 10.5281/zenodo.3785345
Popis: Izha Anna. Тhe role of the internal use of mineral water in the complex treatment of patients with chronic viral hepatitis C with concomitant non-alcoholic fatty liver disease. Journal of Education, Health and Sport. 2020;10(1):226-235. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.01.025 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.01.025 http://dx.doi.org/10.5281/zenodo.3785345 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.12.2019. Revised: 25.12.2019. Accepted: 31.01.2020. ТHE ROLE OF THE INTERNAL USE OF MINERAL WATER IN THE COMPLEX TREATMENT OF PATIENTS WITH CHRONIC VIRAL HEPATITIS C WITH CONCOMITANT NON-ALCOHOLIC FATTY LIVER DISEASE Anna Izha State Institution «Ukrainian Research Institute of Medical Rehabilitation and Balneology of the Ministry of Health of Ukraine», Odessa, Ukraine Abstract Introduction: The use of modern drugs with direct antiviral effect allows achieving a stable virologic response (SVR) in patients with chronic hepatitis C (CHC). However, in most cases, after the elimination of HCV infection, the progression of fibrosis continues with the development of its terminal stages and adverse outcomes for patients. The presence of non-alcoholic fatty liver disease (NAFLD) in these patients significantly increases the rate of progression of fibrosis and its complications, even after reaching SVR. Therefore, the search and development of new non-drug treatment technologies for this category of patients is relevant. Aim: to study the effectiveness of mineral water intake (with a high content of bicarbonates, sodium, potassium, and silicon compounds) in the new mode of use in the complex treatment of patients with chronic hepatitis C with concomitant NAFLD. Methods: anamnestic, clinical, general clinical, biochemical (indicators of lipid metabolism, HOMA index), serological (markers of viral hepatitis C, HCV RNA PCR, qualitative and quantitative determination, genotyping), ultrasonographic studies of the digestive system and statistical methods. Results: Patients with chronic hepatitis C (genotype 1b in the phase of replication, minimal and moderate activity) with concomitant NAFLD, which had been divided into two groups, were examined. Patients of group I (control group) received a standard complex of treatment (diet therapy that corresponded to the Mediterranean diet, dosed exercise regimen, antiviral therapy - sofosbuvir (400 mg) and ledipasvir (90 mg) - 3 months). Patients of group II (the main group) additionally received an internal course intake of mineral water (MW) according to our methodology: 3 ml per kg of patient’s body weight 30-40-60 min before meals, depending on the acidity in the stomach, and the same dose after food intake, three times a day (course - 2 months, a break - 2 months, a second course - 2 months). Evaluation of the effectiveness of treatment was carried out after six months from the start of treatment. Conclusion: The results prove the feasibility and effectiveness of using MW in a doubled dosage regimen in the complex treatment of patients with chronic hepatitis C with chronic concomitant NAFLD, which was determined by improving lipid metabolism, reducing signs of insulin resistance, improving ultrasonographic signs and preventing the development of fibrotic changes in the liver. Keywords: chronic viral hepatitis C; non-alcoholic fatty liver disease; mineral water.
Databáze: OpenAIRE
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