The impact of anorexigenic peptides in experimental models of Alzheimer’s disease pathology
| Autor: | Michal Bencze, Andrea Popelová, Lenka Maletínská, Blanka Železná, Jaroslav Kuneš |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Leptin
0301 basic medicine Pathology medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Type 2 diabetes Disease Neuroprotection Energy homeostasis 03 medical and health sciences 0302 clinical medicine Endocrinology Alzheimer Disease Appetite Depressants Animals Homeostasis Humans Medicine education education.field_of_study business.industry Type 2 Diabetes Mellitus medicine.disease Pyrrolidonecarboxylic Acid Disease Models Animal Neuroprotective Agents 030104 developmental biology Animal studies Energy Metabolism business Oligopeptides 030217 neurology & neurosurgery |
| Zdroj: | Journal of Endocrinology. 240:R47-R72 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1530/joe-18-0532 |
| Popis: | Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder in the elderly population. Numerous epidemiological and experimental studies have demonstrated that patients who suffer from obesity or type 2 diabetes mellitus have a higher risk of cognitive dysfunction and AD. Several recent studies demonstrated that food intake-lowering (anorexigenic) peptides have the potential to improve metabolic disorders and that they may also potentially be useful in the treatment of neurodegenerative diseases. In this review, the neuroprotective effects of anorexigenic peptides of both peripheral and central origins are discussed. Moreover, the role of leptin as a key modulator of energy homeostasis is discussed in relation to its interaction with anorexigenic peptides and their analogs in AD-like pathology. Although there is no perfect experimental model of human AD pathology, animal studies have already proven that anorexigenic peptides exhibit neuroprotective properties. This phenomenon is extremely important for the potential development of new drugs in view of the aging of the human population and of the significantly increasing incidence of AD. |
| Databáze: | OpenAIRE |
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