Progression of symptoms in the early and middle stages of Huntington disease
| Autor: | P. Michael Conneally, Jessica Su, Sandra Close Kirkwood, Tatiana Foroud |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Activities of daily living media_common.quotation_subject Amnesia Disease Arts and Humanities (miscellaneous) Huntington's disease Activities of Daily Living medicine Humans Affective Symptoms Paranoia Psychiatry Depression (differential diagnoses) media_common Chi-Square Distribution Dyskinesias Cognition medicine.disease Health Surveys Sadness Motor Skills Disorders Huntington Disease Regression Analysis Female Neurology (clinical) medicine.symptom Psychology |
| Zdroj: | Archives of neurology. 58(2) |
| ISSN: | 0003-9942 |
| Popis: | Objective To delineate the progression of symptoms in the early and middle stages of Huntington disease (HD). Design A survey of individuals with symptomatic HD completed by a first-degree relative. Setting The National Huntington Disease Research Roster for Patients and Families, Indianapolis, Ind. Participants The survey included 1238 individuals with a minimum of a 6-year history of symptomatic HD. Measures Participating families completed a series of surveys, including the Affected Individual Questionnaire, which consists of 19 physical, emotional, and cognitive signs commonly thought to occur during disease progression. The respondent indicates if each of the symptoms occurred and, if so, at what time during the course of the disease: (1) within 1 year, (2) within 2 to 5 years, (3) within 6 to 10 years, (4) after more than 10 years, (5) has not occurred, or (6) "don't know." Results The symptoms are categorized into 6 onset periods. Involuntary movements are grouped alone as the earliest reported symptom. The second group is composed entirely of mental and emotional symptoms, including sadness, depression, and difficult to get along with. The third group includes clumsiness, sexual problems, lack of motivation, and suspiciousness/paranoia. As the disease progresses, a variety of motor, emotional/behavioral, and cognitive symptoms are experienced, including unsteadiness, trouble holding onto things, trouble walking, changes in sleeping patterns, delusions and hallucinations, intellectual decline, and memory loss. With the approach of late-stage HD, affected individuals begin to experience speech difficulty and weight loss. In the late stage, patients lose bowel and bladder control. Conclusions Even though the symptoms of HD are fairly well characterized, their progression, especially in the early and middle stages, remains uncertain. Clarification of the disease progression is vital to improved understanding of the pathogenesis of HD and to the evaluation of therapeutic agents that are designed to slow the progression of disease. The results of this study assist in clarifying HD progression from early involuntary movements and emotional changes to more overt motor symptoms and difficulty with activities of daily living. |
| Databáze: | OpenAIRE |
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