Mikania glomerata Sprengel (Asteraceae) influences the mutagenicity induced by doxorubicin without altering liver lipid peroxidation or antioxidant levels
| Autor: | Alceu Afonso Jordão, Lilian Cristina Barbosa, Márcio Luis Andrade e Silva, Mariângela Dias de Morais, Camila Alves de Paula, Andréa O. Cecchi, Murilo César da Silva Ferreira, Ademar A. da Silva Filho, Jairo Kenupp Bastos |
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| Rok vydání: | 2012 |
| Předmět: |
Drug
Male Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment media_common.quotation_subject Pharmacology Toxicology Antioxidants Gas Chromatography-Mass Spectrometry chemistry.chemical_compound Mice ANTIOXIDANTES (NÍVEL) medicine Animals Doxorubicin Mikania Adverse effect media_common Micronucleus Tests biology Plant Extracts Vitamin E Glutathione Asteraceae biology.organism_classification Malondialdehyde chemistry Biochemistry Liver Lipid Peroxidation medicine.drug DNA Damage Mutagens |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1528-7394 |
| Popis: | As shown in numerous studies, natural compounds may exert adverse effects, mainly when associated with some drugs. The hydroalcoholic extract of Mikania glomerata is the pharmaceutical form present in commercially available syrup used for the treatment of respiratory diseases in popular Brazilian medicine. The objective of the present investigation was (1) to evaluate the preventive effects of standardized hydroalcoholic extract of M. glomerata (MEx) against antitumoral drug doxorubicin (DXR)-induced micronucleated polychromatic erythrocytes (MNPCE) in a subchronic assay in mice, and (2) to determine the liver content of malondialdehyde (MDA) and the antioxidants glutathione (GSH) and vitamin E (VE). Male Swiss mice were treated for 30 d with MEx added to drinking water, combined or not with DXR (90 mg/kg body weight) injected intraperitoneally (ip) 24 h before analysis. The results demonstrated that MEx produced no genotoxic damage, but significantly increased the frequency of MNPCE induced by DXR, indicating a drug-drug interaction. This rise was not accompanied by lipid peroxidation or antioxidants level reduction, as measured by MDA, GSH, and VE. Despite the presence of coumarin (a known antioxidant), MEx may exert adverse effects probably in association with mutagenic compounds, although this effect on DNA damage did not involve oxidative stress. |
| Databáze: | OpenAIRE |
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