The impact of transcription-mediated replication stress on genome instability and human disease
| Autor: | Yaqun Liu, Chun-Long Chen, Stefano Gnan, Manuela Spagnuolo |
|---|---|
| Přispěvatelé: | Dynamique de l'information génétique : bases fondamentales et cancer (DIG CANCER), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Genome instability
Common fragile sites [SDV.CAN]Life Sciences [q-bio]/Cancer Computational biology DNA replication program [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] Biology Cell cycle Origin of replication Genome 03 medical and health sciences 0302 clinical medicine Transcription (biology) [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Gene duplication Transcription-replication conflicts 030304 developmental biology 0303 health sciences DNA replication Replication stress R-loops Chromatin [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics Human genome Cancers General Economics Econometrics and Finance 030217 neurology & neurosurgery Neurological disorders |
| Zdroj: | Genome Instability & Disease Genome Instability & Disease, Springer, 2020, 1 (5), pp.207-234. ⟨10.1007/s42764-020-00021-y⟩ |
| ISSN: | 2524-7662 |
| Popis: | DNA replication is a vital process in all living organisms. At each cell division, > 30,000 replication origins are activated in a coordinated manner to ensure the duplication of > 6 billion base pairs of the human genome. During differentiation and development, this program must adapt to changes in chromatin organization and gene transcription: its deregulation can challenge genome stability, which is a leading cause of many diseases including cancers and neurological disorders. Over the past decade, great progress has been made to better understand the mechanisms of DNA replication regulation and how its deregulation challenges genome integrity and leads to human disease. Growing evidence shows that gene transcription has an essential role in shaping the landscape of genome replication, while it is also a major source of endogenous replication stress inducing genome instability. In this review, we discuss the current knowledge on the various mechanisms by which gene transcription can impact on DNA replication, leading to genome instability and human disease. |
| Databáze: | OpenAIRE |
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