Evolution of androgen-regulated mRNA expression in mouse kidney
| Autor: | Franklin G. Berger, C Schonfeld, J Tseng-Crank |
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| Rok vydání: | 1988 |
| Předmět: |
Transcription
Genetic Population Biology Kidney Ornithine Decarboxylase medicine.disease_cause Mice Phylogenetics Molecular evolution Gene expression Genetics medicine Animals RNA Messenger education Molecular Biology Gene Phylogeny Ecology Evolution Behavior and Systematics Glucuronidase Mutation education.field_of_study Biological Evolution Phenotype Muridae Gene Expression Regulation Regulatory sequence Androgens |
| Zdroj: | Molecular Biology and Evolution. |
| ISSN: | 1537-1719 |
| DOI: | 10.1093/oxfordjournals.molbev.a040506 |
| Popis: | To gain information on the evolution of mammalian gene expression patterns, we studied the androgen-inducible expression of three kidney mRNAs in several mouse species (genus Mus). The RP2, ornithine decarboxylase, and beta-glucuronidase mRNAs have each evolved independently, in that the pattern of variation among species is unique for each. This suggests a role for gene-specific, cis-acting genetic elements. Relationships between the regulatory phenotypes and the species phylogeny suggest that the variations in hormone-inducible mRNA expression were generated by a series of independent mutations that occurred in specific lineages, resulting in modifications of the progenitor phenotype. Alternatively, the variations may have preexisted within the progenitor population as polymorphisms that were fixed during establishment of individual lineages. Thus, significant alterations in the androgen-regulated mRNA phenotype have occurred either prior to or during speciation within the Mus genus. These alterations are presumed to be in regulatory sequences that control the expression of the corresponding genes and their response to testosterone; as such, they should be useful in further studying the genetic determinants of gene expression and its evolution. |
| Databáze: | OpenAIRE |
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