Cardiac troponin I, cardiac troponin-specific autoantibodies and natriuretic peptides in children with hypoplastic left heart syndrome

Autor: Jaana Pihkala, Eero Jokinen, Tanja Savukoski, Tuija Poutanen, Anneli Eerola, Kim Pettersson, Heikki Sairanen
Rok vydání: 2014
Předmět:
Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Volume overload
macromolecular substances
Fontan Procedure
Norwood Procedures
Hypoplastic left heart syndrome
Fontan procedure
Internal medicine
Troponin I
Hypoplastic Left Heart Syndrome
Natriuretic Peptide
Brain
Medicine
Humans
ta318
Prospective Studies
Protein Precursors
Autoantibodies
biology
business.industry
Infant
Newborn
Infant
Original Articles
musculoskeletal system
medicine.disease
Troponin
Norwood Operation
Peptide Fragments
3. Good health
medicine.anatomical_structure
Cross-Sectional Studies
Treatment Outcome
Ventricle
Case-Control Studies
Child
Preschool
cardiovascular system
biology.protein
Cardiology
Surgery
Norwood procedure
Cardiology and Cardiovascular Medicine
business
Atrial Natriuretic Factor
Biomarkers
Zdroj: Interactive Cardiovascular and Thoracic Surgery. 18(1):80-5
ISSN: 1569-9285
Popis: OBJECTIVES: To evaluate serum levels of cardiac troponin I (cTnI), autoantibodies against cardiac troponin (cTnAAbs) and natriuretic peptides during the treatment protocol in children with hypoplastic left heart syndrome (HLHS). METHODS: In a prospective study, we had 18 consecutive children with HLHS, for whom serum samples were analysed before the Norwood operation, before the bidirectional Glenn (BDG) operation, at the age of one year and before total cavo-pulmonary connection (TCPC). In addition, we performed a cross-sectional study in 22 children examined before TCPC. Controls comprised 34 healthy children. RESULTS: In the prospective study, troponin I was positive in eight children before the Norwood operation. At the next follow-up, six children were positive. Thereafter, in all samples, cTnI was negative. Serum levels of natriuretic peptides decreased during the treatment protocol but remained higher than in controls throughout the study. In the cross-sectional study, cTnI levels were negative, but levels of natriuretic peptides were higher than in controls. Levels of cTnI and natriuretic peptides showed no correlation with oxygen saturation or haemoglobin concentration. Autoantibodies against cardiac troponin appeared in one patient but not in the control children. CONCLUSIONS: Cardiac TnI release is common before Norwood and BDG operations; then during the treatment protocol for HLHS, cTnI release resolves and serum levels of natriuretic peptides decrease. This may reflect a reduction of volume overload of the right ventricle during the surgical programme.
Databáze: OpenAIRE
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