Comparison of medium-term outcomes of living Kidney donors with longitudinal healthy control in the U.K
| Autor: | Lisa Mumford, Paramjit Gill, Neil T Raymond, Nithya Krishnan, Ronan Ryan, Simon Fletcher, Indranil Dasgupta, Graham Lipkin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Renal function Datasets as Topic Kaplan-Meier Estimate 030230 surgery Logistic regression Nephrectomy 03 medical and health sciences Young Adult 0302 clinical medicine Interquartile range Risk Factors Internal medicine Diabetes mellitus Cause of Death Living Donors Medicine Humans Longitudinal Studies Young adult Depression (differential diagnoses) Cause of death Transplantation business.industry Middle Aged medicine.disease Kidney Transplantation United Kingdom Cohort Tissue and Organ Harvesting Kidney Failure Chronic 030211 gastroenterology & hepatology Female business Follow-Up Studies |
| ISSN: | 0041-1337 |
| Popis: | BACKGROUND Understanding the outcomes and risks for live kidney donors (LD) is increasingly important; this study investigated all-cause mortality and morbidity outcomes of LD compared with a healthy cohort. METHODS Live donor dataset was obtained from the UK Transplant Registry and a comparator nondonor cohort selected from The Health Improvement Network (THIN) database, a UK primary healthcare database. All LD from January 1, 2001, to December 31, 2013, were included, with follow-up until December 31, 2016. RESULTS There were 9750 LD and 19 071 THIN participants. Median follow-up (interquartile range) for LD was 8.4 (6.0-11.3) years and for THIN was 5.4 (2.6-8.5) years. In up to 15 years, follow-up end-stage renal disease was observed in 1 LD versus 7 THIN (P = 0.280). Nine LD had estimated glomerular filtration rate of |
| Databáze: | OpenAIRE |
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