In Vivo anti-trypanosomal activity of dichloromethane and methanol crude leaf extracts of Dovyalis abyssinica (Salicaceae) against Trypanosoma congolense

Autor: Workineh Shibeshi, Belay Tadesse, Nigatu Kebede, Getachew Terefe
Rok vydání: 2015
Předmět:
Zdroj: BMC Complementary and Alternative Medicine
ISSN: 1472-6882
DOI: 10.1186/s12906-015-0809-y
Popis: Background African trypanosomiasis affects both humans and livestock in sub-Saharan countries including Ethiopia. Due to limitations to current chemotherapy, there is an urgent need for the development of new, safe, cheap and effective drugs. In the present study, the leaf of Dovyalis abyssinica was tested for its in vivo antitrypanosomal activity against Trypanosoma congolense field isolate on mice. Methods The leaf of D. abyssinica was macerated using dichloromethane and methanol. The extracts at doses of 250, 200, 150 and 100 mg/kg body weight were administered intraperitonealy daily for 7 days to mice infected with T. congolense. Following administration, parasitemia, packed cell volume, rectal temperature, body weight and survival time were monitored. Results Administration of dichloromethane and methanol extracts at 250 and 200 mg/kg reduced (p
Databáze: OpenAIRE
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