A novel wound dressing material: Pullulan grafted copolymer hydrogel via UV copolymerization and crosslinking
| Autor: | Humeyra Mert, Hüdanur Damar, Bengi Özkahraman |
|---|---|
| Přispěvatelé: | [Belirlenecek], Özkahraman, Bengi |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pharmaceutical Science
Salt (chemistry) 02 engineering and technology 030226 pharmacology & pharmacy Pullulan 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Copolymer MTT assay Itaconic acid Antibiotic release Acrylic acid chemistry.chemical_classification Chemistry 021001 nanoscience & nanotechnology Hydrogel Wound dressing Ampicillin Sodium Drug delivery Swelling medicine.symptom 0210 nano-technology Nuclear chemistry |
| Popis: | This study presents the preparation and characterization of pullulan grafted copolymer hydrogel as a new wound dressing material. In this regard, pullulan grafted copolymer hydrogel (PGH) was prepared via UV copolymerization and crosslinking reactions of acrylic acid and itaconic acid onto pullulan. Ampicillin sodium salt loaded PGH was also prepared in the same manner with the addition of the drug in the reaction medium. In-vitro drug release experiments showed that 67% of the loaded drug was released from the PGHs after 7 days. Swelling studies performed at different pH conditions confirmed the high swelling capacities of PGHs (i.e., 700%). Besides, MTT assay showed that L929 cell viability could overpass 80% for PGHs. These results revealed that the prepared non-cytotoxic PGHs are promising candidates for wound dressing applications. 2-s2.0-85090723329 |
| Databáze: | OpenAIRE |
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