Personalised fractional flow reserve: a novel concept to optimise myocardial revascularisation
| Autor: | Patricia V. Lawford, R.D. Gosling, Paul Morris, Julian Gunn, D. R. Hose |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Context (language use) Coronary Artery Disease Fractional flow reserve 030204 cardiovascular system & hematology Coronary Angiography Normal artery 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Internal medicine Myocardial Revascularization medicine Humans cardiovascular diseases 030212 general & internal medicine Flow restoration medicine.diagnostic_test business.industry Myocardial revascularisation Percutaneous coronary intervention Fractional Flow Reserve Myocardial Treatment Outcome surgical procedures operative Conventional PCI Angiography Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | EuroIntervention. 15:707-713 |
| ISSN: | 1774-024X |
| Popis: | AIMS Fractional flow reserve (FFR) represents the percentage reduction in coronary flow relative to a hypothetically normal artery; however, percutaneous coronary intervention (PCI) seldom achieves physiological normality (FFR 1.00), particularly in the context of diffuse disease. In this study we describe a method for calculating the vessel-specific maximal achievable FFR (FFRmax) providing a personalised assessment of what PCI can achieve. METHODS AND RESULTS FFR measurements were obtained from 71 patients (100 arteries) undergoing angiography. Three-dimensional (3D) coronary anatomy was reconstructed from angiographic images. An ideal intervention, in which all stenoses are removed, was modelled, and the FFRmax calculated. The "personalised" FFR (FFRpers) was calculated as measured FFR/FFRmax. PCI was performed in 52 vessels and post-PCI FFR measured in 50. FFRmax was compared to post-PCI measured FFRs. The mean FFRmax was 0.92 (±0.04). This was on average 0.04 (±0.05) higher than the corresponding post-PCI measured FFR (p |
| Databáze: | OpenAIRE |
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