Tandem Synthesis of 1,2,3-Thiadiazoles with 3,4-Dichloroisothiazoles and Hydrazines under External Oxidant- and Sulfur-Free Conditions

Autor:	Yue Zhang, Kun Li, Wei Gao, Xiaoyu Liu, Haolin Yuan, Liangfu Tang, Zhijin Fan
Rok vydání:	2022
Předmět:	Biological Products Hydrazines Thiadiazoles Organic Chemistry Ketones Physical and Theoretical Chemistry Oxidants Biochemistry Sulfur
Zdroj:	Organic Letters. 24:6599-6603
ISSN:	1523-7052 1523-7060
Popis:	1,2,3-Thiadiazoles are among the most important heterocyclic motifs, with wide applications in natural products and medicinal chemistry. Herein, we disclose a tandem reaction for the synthesis of structurally diverse 1,2,3-thiadiazoles from 3,4-dichloroisothiazol-5-ketones and hydrazines. This method is characterized by mild external oxidant- and sulter-free reaction conditions, a broad substrate scope, and easy purification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7df92b080d5b68c9fc28074ef547a7 https://doi.org/10.1021/acs.orglett.2c02595 Zobrazit plný text záznamu