Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery
| Autor: | W. Chayoua, Tom G. Mastenbroek, Judith M.E.M. Cosemans, Daniëlle Coenen, Magdolna Nagy, Marijke J.E. Kuijpers, Joke Konings, Peter Leenders, Stefan Heitmeier, A. E. Brouns, R. van Oerle, Henri M. H. Spronk, H. van Essen, E. I. J. Korsten, Jacques Debets, Mieke F.A. Karel |
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| Přispěvatelé: | RS: Carim - B07 The vulnerable plaque: makers and markers, RS: Carim - H03 ECM and Wnt signaling, CTR, Biochemie, RS: MERLN - Complex Tissue Regeneration (CTR), RS: Carim - B03 Cell biochemistry of thrombosis and haemostasis, RS: Carim - B04 Clinical thrombosis and Haemostasis, RS: Carim - B01 Blood proteins & engineering, Farmacologie en Toxicologie |
| Rok vydání: | 2020 |
| Předmět: |
Carotid Artery Diseases
Male 0301 basic medicine lcsh:Medicine 030204 cardiovascular system & hematology Pharmacology Carotid Intima-Media Thickness P-SELECTIN EXPRESSION Mice 0302 clinical medicine Rivaroxaban Leukocytes Medicine Platelet lcsh:Science Aspirin Multidisciplinary STIFFNESS Arteries ANTIPLATELET Cardiovascular diseases Carotid Arteries medicine.anatomical_structure CLOPIDOGREL cardiovascular system medicine.drug Artery Platelets Blood Platelets RECRUITMENT COAGULATION Article Vascular remodelling in the embryo PLATELET-LEUKOCYTE INTERACTIONS 03 medical and health sciences Animal disease models In vivo WHOLE-BLOOD Animals Thrombus business.industry lcsh:R Thrombosis medicine.disease Mice Inbred C57BL THROMBUS FORMATION 030104 developmental biology Microscopy Electron Scanning lcsh:Q CORONARY business Ligation Platelet Aggregation Inhibitors Factor Xa Inhibitors |
| Zdroj: | Scientific Reports, 10(1):19360. Nature Publishing Group Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-76377-8 |
| Popis: | While in recent trials the dual pathway inhibition with aspirin plus rivaroxaban has shown to be efficacious in patients with atherosclerotic cardiovascular disease, little is known about the effects of this combination treatment on thrombus formation and vascular remodelling upon vascular damage. The aim of this study was to examine the effects of aspirin and/or rivaroxaban on injury-induced murine arterial thrombus formation in vivo and in vitro, vessel-wall remodelling, and platelet-leukocyte aggregates. Temporary ligation of the carotid artery of C57BL/6 mice, fed a western type diet, led to endothelial denudation and sub-occlusive thrombus formation. At the site of ligation, the vessel wall stiffened and the intima-media thickened. Aspirin treatment antagonized vascular stiffening and rivaroxaban treatment led to a positive trend towards reduced stiffening. Local intima-media thickening was antagonized by both aspirin or rivaroxaban treatment. Platelet-leukocyte aggregates and the number of platelets per leukocyte were reduced in aspirin and/or rivaroxaban treatment groups. Furthermore, rivaroxaban restricted thrombus growth and height in vitro. In sum, this study shows vascular protective effects of aspirin and rivaroxaban, upon vascular injury of the mouse artery. |
| Databáze: | OpenAIRE |
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