Duration of EEG suppression does not predict recovery time or degree of cognitive impairment after general anaesthesia in human volunteers
| Autor: | Brian Litt, Connor Brennan, L.B. Hickman, Ellen Janke, Hannah R. Maybrier, Nan Lin, Brenna P. Shortal, Maxwell R. Muench, Wei Wang, Max B. Kelz, Paul Picton, Ben J.A. Palanca, George A. Mashour, R.A. Mak-McCully, Stefanie Blain-Moraes, Andrew R. McKinstry-Wu, Hoameng Ung, Alex Proekt, Vijay Tarnal, Michael S. Avidan |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty media_common.quotation_subject Electroencephalography Audiology Anesthesia General Time 03 medical and health sciences Young Adult 0302 clinical medicine Neuroscience and Neuroanaesthesia 030202 anesthesiology Predictive Value of Tests Reference Values medicine Humans General anaesthesia Cognitive Dysfunction media_common Psychomotor learning medicine.diagnostic_test business.industry Brain Cognition Healthy Volunteers Burst suppression Anesthesiology and Pain Medicine Isoflurane Digit symbol substitution test Anesthesia Recovery Period Female business Vigilance (psychology) medicine.drug |
| Zdroj: | Br J Anaesth |
| Popis: | Background Burst suppression occurs in the EEG during coma and under general anaesthesia. It has been assumed that burst suppression represents a deeper state of anaesthesia from which it is more difficult to recover. This has not been directly demonstrated, however. Here, we test this hypothesis directly by assessing relationships between EEG suppression in human volunteers and recovery of consciousness. Methods We recorded the EEG of 27 healthy humans (nine women/18 men) anaesthetised with isoflurane 1.3 minimum alveolar concentration (MAC) for 3 h. Periods of EEG suppression and non-suppression were separated using principal component analysis of the spectrogram. After emergence, participants completed the digit symbol substitution test and the psychomotor vigilance test. Results Volunteers demonstrated marked variability in multiple features of the suppressed EEG. In order to test the hypothesis that, for an individual subject, inclusion of features of suppression would improve accuracy of a model built to predict time of emergence, two types of models were constructed: one with a suppression-related feature included and one without. Contrary to our hypothesis, Akaike information criterion demonstrated that the addition of a suppression-related feature did not improve the ability of the model to predict time to emergence. Furthermore, the amounts of EEG suppression and decrements in cognitive task performance relative to pre-anaesthesia baseline were not significantly correlated. Conclusions These findings suggest that, in contrast to current assumptions, EEG suppression in and of itself is not an important determinant of recovery time or the degree of cognitive impairment upon emergence from anaesthesia in healthy adults. |
| Databáze: | OpenAIRE |
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