Effects of phospholipid based formulations on in vitro and in vivo percutaneous absorption of methyl nicotinate
| Autor: | Lucia Montenegro, Claudio Nastruzzi, Elisabetta Esposito, Francesco Bonina, Rita Cortesi, Enea Menegatti, N. Scrofani |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
food.ingredient
Phospholipid Pharmaceutical Science vehicle effects Absorption (skin) Lecithin Dosage form chemistry.chemical_compound Phospholipids Liposome Microemulsion Methyl nicotinate Reflectance spectrophotometry Skin permeation food In vivo medicine Chromatography integumentary system Permeation Carboxymethyl cellulose chemistry lipids (amino acids peptides and proteins) skin permeation phospholipids medicine.drug |
| Popis: | In this paper we evaluate the influence of phospholipid based formulations (PBFs) on skin absorption. In particular we describe the production and characterization of different PBFs, namely liposomes and w/o microemulsion gels, and their influence on in vitro and in vivo absorption of methyl nicotinate (MN) used as model compound. In order to compare the influence of various vehicles on skin absorption, Franz cell and MN induced erythema were used as in vitro and in vivo experimental models respectively. The formulations tested were: (a) unilamellar liposomes consisting of soybean lecithin/ cholesterol (9:1 w/w) suspended in water or incorporated into hydrophilic gels (Carbomer and carboxymethyl cellulose based gels) and (b) soybean lecithin based gels. The results indicate that vehicles containing phospholipids in liposomal form provided enhanced in vivo MN skin permeation compared to the corresponding vehicles without phospholipids. Lecithin gel showed a different behaviour characterized by a short and intense persistence of MN induced erythema. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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