Aerobic interval exercise improves renal functionality and affects mineral metabolism in obese Zucker rats
| Autor: | Carlos López-Chaves, Francisco Arrebola, Rosario Martínez, Pilar Aranda, Irene Coll-Risco, Elena Cáceres, Garyfallia Kapravelou, María López-Jurado, Cristina Sánchez-González, Milagros Galisteo, Juan Llopis, Jesús M. Porres |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Time Factors Physiology 030232 urology & nephrology Type 2 diabetes High-Intensity Interval Training Kidney Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Glomerulonephritis Internal medicine medicine aerobic interval training Mineral metabolism Albuminuria Animals Femur Obesity Chronic Kidney Disease-Mineral and Bone Disorder Minerals business.industry diabetic nephropathy Glomerulosclerosis Hypertrophy Recovery of Function medicine.disease Zucker rat mineral metabolism Rats Zucker Disease Models Animal 030104 developmental biology medicine.anatomical_structure Endocrinology Metabolic syndrome business glomerulosclerosis Biomarkers Kidney disease |
| Zdroj: | American journal of physiology. Renal physiology. 316(1) |
| ISSN: | 1522-1466 |
| Popis: | Obesity, metabolic syndrome, and renal injury are considered risk factors for type 2 diabetes, as well as kidney disease. Functional and structural changes in the kidney as consequence of obesity and metabolic syndrome may lead to impaired mineral metabolism in what is known as chronic kidney disease-mineral and bone disorder. Lifestyle interventions such as physical activity are good strategies to manage these pathologies and therefore, prevent the loss of kidney functionality and related complications in mineral metabolism. In this study, we have used 40 male Zucker rats that were randomly allocated into four different experimental groups, two of them (an obese and a lean one) performed an aerobic interval training protocol, and the other two groups were sedentary. At the end of the experimental period (8 wk), urine, plasma, and femur were collected for biochemical and mineral composition analysis, whereas the kidney was processed for histological studies. The obese rats exhibited albuminuria, glomerulosclerosis, and hypertrophy in glomeruli and renal tubule in some areas, together with alterations in mineral content of plasma but not of femur. The training protocol prevented the generation of albuminuria and glomerulosclerosis, showing a significant action on plasma and bone mineral levels. Therefore, the specific training protocol used in this study was able to prevent the development of diabetic nephropathy and affected the metabolism of certain minerals. |
| Databáze: | OpenAIRE |
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