Dietary fish oil supplementation during early pregnancy in rats on a cafeteria-diet prevents fatty liver in adult male offspring
| Autor: | Clara Sánchez-Blanco, Kenia Bispo, Emilio Herrera, Encarnación Amusquivar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Offspring Biology Toxicology Rats Sprague-Dawley 03 medical and health sciences 0404 agricultural biotechnology Fish Oils Sex Factors Pregnancy Internal medicine Lactation medicine Weaning Animals Humans Triglycerides 030304 developmental biology chemistry.chemical_classification 0303 health sciences Fatty liver Fatty Acids Fatty acid 04 agricultural and veterinary sciences General Medicine medicine.disease Fish oil 040401 food science Diet Rats Fatty Liver medicine.anatomical_structure Endocrinology chemistry Liver Prenatal Exposure Delayed Effects Dietary Supplements Gestation Female Food Science |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 123 |
| ISSN: | 1873-6351 |
| Popis: | We studied in rats the effects of cafeteria diet (CD) supplemented (or not) with fish oil (FO) during just the first 12 days of pregnancy, or during the whole of pregnancy and lactation in 14-month old offspring. Female rats were given standard diet (STD) or CD and after mating some animals remained on STD or CD; for some CD rats the diet was supplemented with 8.78% FO. After 12 days, half of the CD-FO group returned to CD (CD-FO12) and the others remained on CD-FO. From weaning all offspring were given STD. The adiposity index of male offspring of CD dams increased but was normal in CD-FO males. Plasma triacylglycerols (TAG) and individual fatty acid concentrations were similar among the groups. Liver total lipids, TAG, fatty acid concentrations, Δ9-desaturase indices and the mRNA expression of fatty acid synthase were higher in male offspring of CD than in those of STD; most of these differences disappeared in male offspring of CD-FO12 and CD-FO dams. Female offspring showed smaller changes. Thus, a moderate supplement with FO during just the first half of gestation or during pregnancy and lactation in rats on CD decreases the liver steatosis in male adult offspring. |
| Databáze: | OpenAIRE |
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