Pediatric implications of multiple endocrine neoplasia
| Autor: | David Girvan, Ronald L. Holliday |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Calcitonin
Male medicine.medical_specialty Pediatrics Medullary cavity medicine.medical_treatment Adrenal Gland Neoplasms Pheochromocytoma Thyroid carcinoma Internal medicine medicine Humans Endocrine system Thyroid Neoplasms Family history Child Multiple endocrine neoplasia business.industry Hyperparathyroidism Carcinoma Multiple Endocrine Neoplasia Thyroidectomy General Medicine medicine.disease Pentagastrin Endocrinology Pediatrics Perinatology and Child Health Surgery business medicine.drug |
| Zdroj: | Journal of Pediatric Surgery. 22:806-808 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/s0022-3468(87)80640-1 |
| Popis: | The association of endocrine tumors from several sites has been known for over 50 years but the familial aspects of these relationships have only been appreciated since 1954. The original term multiple familial endocrine adenomatosis (MEA) was changed to multiple endocrine neoplasia (MEN). This report describes two children aged 8 and 11 years, who are cousins with MEN IIa. A strong family history prompted investigation of these children. Pentagastrin stimulation resulted in elevated serum calcitonin levels and subsequent surgery. Unsuspected medullary thyroid carcinoma was found in each child. Proper screening of high-risk individuals should prevent this potentially lethal condition from becoming a major problem. |
| Databáze: | OpenAIRE |
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