Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics
| Autor: | You-Nian Liu, Xiaoyuan Ji, Chan Feng, Na Tao, Zhongmin Tang, Tianfeng Chen, Jiang Ouyang, Wei Chen, Na Kong, Wei Tao, Ling Zhang, Leijiao Li |
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| Rok vydání: | 2020 |
| Předmět: |
Two-dimensional
Materials science Biocompatibility lcsh:T Cancer theranostics Nanotechnology Photothermal therapy lcsh:Technology Exfoliation joint Biological materials Article Cryogenic exfoliation Surfaces Coatings and Films Electronic Optical and Magnetic Materials Nanomedicine Average size Stanene PEGylation Electrical and Electronic Engineering |
| Zdroj: | Nano-Micro Letters Nano-Micro Letters, Vol 13, Iss 1, Pp 1-18 (2021) |
| ISSN: | 2150-5551 |
| Popis: | Highlights 2D Sn nanosheets (SnNSs) were prepared through the combination of cryogenic exfoliation and liquid-phase exfoliation.The functionalized 2D SnNSs have good stability, superior biocompatibility, high photothermal conversion efficiency, and multimode imaging capability. Supplementary Information The online version contains supplementary material available at 10.1007/s40820-021-00619-1. Stanene (Sn)-based materials have been extensively applied in industrial production and daily life, but their potential biomedical application remains largely unexplored, which is due to the absence of the appropriate and effective methods for fabricating Sn-based biomaterials. Herein, we explored a new approach combining cryogenic exfoliation and liquid-phase exfoliation to successfully manufacture two-dimensional (2D) Sn nanosheets (SnNSs). The obtained SnNSs exhibited a typical sheet-like structure with an average size of ~ 100 nm and a thickness of ~ 5.1 nm. After PEGylation, the resulting PEGylated SnNSs (SnNSs@PEG) exhibited good stability, superior biocompatibility, and excellent photothermal performance, which could serve as robust photothermal agents for multi-modal imaging (fluorescence/photoacoustic/photothermal imaging)-guided photothermal elimination of cancer. Furthermore, we also used first-principles density functional theory calculations to investigate the photothermal mechanism of SnNSs, revealing that the free electrons in upper and lower layers of SnNSs contribute to the conversion of the photo to thermal. This work not only introduces a new approach to fabricate 2D SnNSs but also establishes the SnNSs-based nanomedicines for photonic cancer theranostics. This new type of SnNSs with great potential in the field of nanomedicines may spur a wave of developing Sn-based biological materials to benefit biomedical applications. Supplementary Information The online version contains supplementary material available at 10.1007/s40820-021-00619-1. |
| Databáze: | OpenAIRE |
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