Mouse lysozyme M gene: isolation, characterization, and expression studies
| Autor: | Angela Wedel, Rainer Renkawitz, Inge Mangelsdorf, Michael Cross |
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| Rok vydání: | 1988 |
| Předmět: |
Transcription
Genetic Molecular Sequence Data Biology Isozyme chemistry.chemical_compound Mice Complementary DNA Gene expression Animals Amino Acid Sequence RNA Messenger Cloning Molecular Peptide sequence Gene Multidisciplinary Base Sequence Nucleic acid sequence DNA Molecular biology Isoenzymes genomic DNA chemistry Genes Organ Specificity Muramidase Lysozyme Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 85(17) |
| ISSN: | 0027-8424 |
| Popis: | We have isolated and characterized both cDNA and genomic DNA of the mouse lysozyme M gene. Derivation of the amino acid sequence from the nucleotide sequences revealed six positions in the carboxyl terminus that differ from partial sequences previously published. The differential detection of specific mRNAs from the closely related lysozyme M and P genes has revealed different but overlapping tissue specificities of expression. The M gene is expressed weakly in myeloblasts, moderately in immature macrophages, and strongly in both mature macrophages and macrophage-rich tissues, while high levels of P transcripts are present only in small intestine. Sites of protein accumulation, rather than gene expression, have been identified by comparative quantitation of mRNA and enzyme levels. |
| Databáze: | OpenAIRE |
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