Quantitative Trait Loci Mapping of Serum IgE in an Isolated Hutterite Population
| Autor: | Rita M. Cantor, Maricela Alarcón |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male 0301 basic medicine Chromosomes Human Pair 21 Epidemiology Population 030105 genetics & heredity Quantitative trait locus Immunoglobulin E Serum ige Consanguinity 03 medical and health sciences Quantitative Trait Heritable Gene Frequency Genetic model Humans Child education Gene Genetics (clinical) Genetics Analysis of Variance education.field_of_study biology Chromosome Mapping Major gene Asthma Genetics Population 030104 developmental biology Chromosomes Human Pair 1 South Dakota biology.protein Female Founder effect |
| Zdroj: | Genetic Epidemiology. 21:S224-S229 |
| ISSN: | 0741-0395 |
| DOI: | 10.1002/gepi.2001.21.s1.s224 |
| Popis: | Serum immunoglobulin E (IgE) is a quantitative trait associated with asthma. A variance components approach to the analysis of data from a subset of a founder population of Hutterites indicated that over half the variability in IgE levels may be due to genes. Two variance components methods suggest that the genetic model underlying IgE does not consist of a single major gene, but of multiple loci with more modest effects. Both approaches identified putative quantitative trait loci on chromosomes 1 and 21. |
| Databáze: | OpenAIRE |
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