IL-17A promotes the proliferation of human nasopharyngeal carcinoma cells through p300-mediated Akt1 acetylation
| Autor: | Kemin Cai, Bing Wang, Ronglan Luan, Xueli Bao, Jiusheng Chu, Hongmei Dou |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research proliferation medicine.medical_treatment Cell AKT1 Biology 03 medical and health sciences 0302 clinical medicine AKT serine/threonine kinase 1 otorhinolaryngologic diseases medicine Protein kinase B acetylation nasopharyngeal carcinoma Articles Cell cycle medicine.disease stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Cytokine Oncology Nasopharyngeal carcinoma Acetylation 030220 oncology & carcinogenesis Cancer research interluekin-17A E1A binding protein p300 A431 cells |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | Interleukin (IL)-17A is a T helper (Th)17 cell-secreted cytokine that is able to induce various inflammatory responses. There is emerging evidence that IL-17A is generated in the cancer microenvironment of human nasopharyngeal carcinoma (NPC). However, the role of IL-17A in NPC remains unclear. Thus, the present study aimed to examine the direct influence of IL-17A stimulation on the proliferation of human NPC cells and identify the underlying molecular mechanisms. Furthermore, E1A binding protein p300 (p300)-mediated AKT serine/threonine kinase 1 (Akt1) acetylation and its role in regulating the proliferation of NPC cells was investigated. The results of the current study demonstrated that IL-17A stimulation in vitro increased the proliferation of human NPC cells. Furthermore, Akt1 acetylation was identified to be enhanced in human NPC cells induced by IL-17A. Additionally, p300 induction was demonstrated to be required for Akt1 acetylation in human NPC cells following exposure to IL-17A. Functionally, p300-mediated Akt1 acetylation contributed to the proliferation of human NPC cells stimulated by IL-17A. In conclusion, the results of the present demonstrate a novel activity of IL-17A that promotes human NPC cell proliferation via p300-mediated Akt1 acetylation. This may provide a potential strategy for the treatment of patients with NPC through the inhibition of IL-17A or its receptors. |
| Databáze: | OpenAIRE |
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