Cytotoxic Halogenated Metabolites from the Brazilian Red Alga Laurencia catarinensis
| Autor: | Miriam Falkenberg, Vassilios Roussis, Paulo Antunes Horta, Antonio Quesada, Cintia Lhullier, Efstathia Ioannou, Constantinos Vagias, Eloir Paulo Schenkel, Panagiota Papazafiri |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Stereochemistry
Chemical structure Metabolite In vitro cytotoxicity Pharmaceutical Science Antineoplastic Agents Pharmacognosy Crystallography X-Ray Laurencia Analytical Chemistry chemistry.chemical_compound Drug Discovery Humans Cytotoxicity Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure Hydrocarbons Halogenated Chemistry Organic Chemistry Absolute configuration Complementary and alternative medicine Epidermoid carcinoma Molecular Medicine Female Drug Screening Assays Antitumor HT29 Cells Laurencia catarinensis Brazil |
| Zdroj: | Journal of Natural Products. 73:27-32 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np900627r |
| Popis: | Seven new (1-7) and seven previously reported (8-14) halogenated metabolites were isolated from the organic extract of the Brazilian red alga Laurencia catarinensis. The structure elucidation and the assignment of the relative configurations of the new natural products were based on detailed NMR and MS spectroscopic analyses, whereas the structure of metabolite 6 was confirmed by single-crystal X-ray diffraction analysis. The absolute configuration of metabolite 1 was determined using the modified Mosher's method. The in vitro cytotoxicity of compounds 1-14 was evaluated against HT29, MCF7, and A431 cell lines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|