The protective effect of modified intravenous immunoglobulin in LPS sepsis model is associated with an increased IRA B cells response
| Autor: | Shina Pashova, Anastas Pashov, Iglika K Djoumerska-Alexieva, Tchavdar L. Vassilev |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Lipopolysaccharides
Iron Immunology Population Spleen Sepsis Mice 03 medical and health sciences Peritoneal cavity 0302 clinical medicine Biological property hemic and lymphatic diseases medicine Animals Immunologic Factors Immunology and Allergy education CD93 Peritoneal Cavity Cells Cultured 030304 developmental biology B-Lymphocytes Mice Inbred ICR 0303 health sciences education.field_of_study biology business.industry Immunoglobulins Intravenous medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Antibody business Intracellular |
| Zdroj: | Autoimmunity reviews |
| DOI: | 10.1016/j.autrev.2012.10.010 |
| Popis: | Intravenous immunoglobulin preparations (IVIg) that have undergone a mild oxidizing treatment with ferrous ions have an increased polyspecificity, which is not associated with a higher propensity to form aggregates. Among other biological properties of the modified IVIg, a protective effect in LPS sepsis model stands out as the native preparation is totally devoid of it or even exacerbates sepsis. A recent finding identified an LPS induced subset of B1 lymphocytes that migrate from the peritoneal cavity to the spleen acquiring the expression of CD93, GM-CSF as well as the capacity to control sepsis. This report demonstrates that modified IVIg, but not the native preparation, causes a further increase in this population during LPS sepsis. Partial targeted suppression of the peritoneal B cell proliferation by an intracellular dye abrogates this effect and the clinical benefit of modified IVIg. |
| Databáze: | OpenAIRE |
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