Treatment of climacteric symptoms with an ammonium succinate-based dietary supplement: a randomized, double-blind, placebo-controlled trial

Autor:	A A Osmakova, N B Repina, D I Burchakov, Y K Gusak, V E Radzinskii, I V Kuznetsova, O M Zubova, Yu B Uspenskaya
Rok vydání:	2016
Předmět:	Adult medicine.medical_specialty Endocrinology Diabetes and Metabolism Dietary supplement Succinic Acid Placebo-controlled study 030209 endocrinology & metabolism Double blind 03 medical and health sciences 0302 clinical medicine Endocrinology Double-Blind Method Internal medicine Outcome Assessment Health Care medicine Humans Vitamin E Gynecology Minerals 030219 obstetrics & reproductive medicine Postmenopausal women Vasomotor business.industry Obstetrics and Gynecology Middle Aged medicine.disease Menopause Ammonium Succinate Dietary Supplements Female Climacteric business
Zdroj:	Gynecological Endocrinology. 32:64-68
ISSN:	1473-0766 0951-3590
Popis:	Peri- and postmenopausal women commonly suffer from climacteric symptoms. We evaluated the effectiveness and safety of dietary supplement Amberen to relieve vasomotor and psychosomatic symptoms during the course of a 3-month, randomized, double-blind, placebo-controlled study. General clinical assessment, evaluation using the Greene climacteric test and Spielberger-Hanin test, determination of plasma levels of gonadotropins, estradiol, leptin and apolipoproteins were used to evaluate 42-60-year-old women with vasomotor and psychosomatic menopausal symptoms. One hundred and twenty-five women were enrolled in the study and randomized between two groups. Based on the Greene test results, there was a statistically significant improvement (р 0.05) in 13 out of 21 menopausal symptoms in women who took Amberen. During the course and by the end of the study, patients showed statistically significant changes in the levels of estradiol, gonadotropins and leptin, and decreases in body weight and waist circumference. Spielberger-Hanin test showed that Amberen stabilizes patients' psychological state with a statistically significant decrease in anxiety, increased stress resistance and improved adaptability. Comparative analysis of the vital signs measurements, blood tests and urinalysis did not show any negative effects of Amberen on the patients. Our findings indicate that Amberen can be considered a method of choice to relief mild/moderate climacteric symptoms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6fdc59069bbd43688b1cff16838373 https://doi.org/10.1080/09513590.2016.1232686 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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