Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer
| Autor: | Hsin-Jung Li, Zi-Xian Liao, Kuo-Yen Huang, S-Ja Tseng, Ivan M. Kempson, Pan-Chyr Yang |
|---|---|
| Přispěvatelé: | Liao, Zi Xian, Huang, Kuo Yen, Kempson, Ivan M, Li, Hsin Jung, Tseng, S Ja, Yang, Pan Chyr |
| Rok vydání: | 2020 |
| Předmět: |
Lung Neoplasms
medicine.drug_class medicine.medical_treatment Pharmaceutical Science Drug resistance Tyrosine-kinase inhibitor Targeted therapy In vivo Carcinoma Non-Small-Cell Lung Humans Medicine Epidermal growth factor receptor Lung cancer Protein Kinase Inhibitors EGFR-TKIs resistance nanotechnology biology business.industry Kinase medicine.disease respiratory tract diseases ErbB Receptors Drug Resistance Neoplasm Mutation Cancer research biology.protein Nanocarriers epidermal growth factor receptor business |
| Zdroj: | Journal of Controlled Release. 324:482-492 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2020.05.043 |
| Popis: | Lung cancer is the primary cause of cancer-related death worldwide. 85%–90% of cases are non-small cell lung cancer (NSCLC) which characteristically exhibits altered epidermal growth factor receptor (EGFR) signaling is a major driver pathway. Unfortunately, therapeutic outcomes in treating NSCLC are compromised by the emergence of drug resistance in response to EGFR-tyrosine kinase inhibitor (TKI) targeted therapy due to the acquired resistance mutation EGFR T790M or activation of alternative pathways. There is current need for a new generation of TKIs to be developed to treat EGFR-TKI-resistant NSCLC. To overcome the above problems and improve clinical efficacy, nanotechnology with targeting abilities and sustained release has been proposed for EGFR-TKI-resistant NSCLC treatment and has already achieved success in in vitro or in vivo models. In this review, we summarize and illustrate representative nano-formulations targeting EGFR-TKI-resistant NSCLC. The described advances may pave the way to better understanding and design of nanocarriers and multifunctional nanosystems for efficient treatment for drug resistant NSCLC. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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