| Autor: |
Xiaotian Zhang, Liling Wan, Shasha Chong, Jianzhong Su, Jolanta Grembecka, Tomasz Cierpicki, Gerd P. Pfeifer, Pamela Himadewi, Haley Gore, Dong Chen, Qinglan Li, Xinyu Wang, Hongzhi Miao, Yiman Liu, Qinyu Han, Dandan Fan, Xue Qing David Wang |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Figure S1 is associated with Figure1 and it shows the NPM1-WT binds to the rDNA arrays and NPM1c binds to non-repetitive genomic regions. Supplementary Figure S2 is associated with Figure1 and it shows NPM1c’s chromatin binding and association with gene expression. Supplementary Figure S3 is associated with Figure2 and shows NPM1c regulates the transcription of its target genes with BRU-seq. Supplementary Figure S4 is associated with Figure2 and it shows the characterization of NPM1c condensate with biochemical assay and imaging assay. Supplementary Figure S5 is associated with figure 3. The figure shows NPM1c and chromatin landacpe dymanics during dTag-13 treatment and wash-off. Supplementary Figure S6 is associated with figure 4. It shows the supplemental data of HOXB8-NPM1c-knock-in model. Supplementary figure S7 is associated with figure 5. It shows the supplemental data of XPO1's binding to chromatin in various leukemia cell lines and normal HSPCs. Supplementary Figure S8 is associated with figure 6. It shows the supplemental information of synergy between Menin and XPO1 inhibitor in the NPM1c AML cell line model. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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