The Effect of Low-Dose Corticosteroids on Short- and Long-Term Renal Outcome in Patients with Cholesterol Crystal Embolism

Autor:	Masaharu Nagata, Masaru Nakayama, Kensuke Izumaru, Kazunori Urabe, Yuko Ohta, Takuya Tsuchihashi, Eri Hasegawa, Hirofumi Ikeda, Kanako Nishida
Rok vydání:	2011
Předmět:	Male medicine.medical_specialty Urology Renal function Kidney Function Tests Critical Care and Intensive Care Medicine chemistry.chemical_compound Asian People Adrenal Cortex Hormones medicine Humans Eosinophilia In patient Longitudinal Studies Renal Insufficiency Chronic Aged Embolism Cholesterol Retrospective Studies Aged 80 and over Cholesterol business.industry Low dose Retrospective cohort study General Medicine Middle Aged medicine.disease Surgery Treatment Outcome Steroid therapy chemistry Embolism Nephrology Female medicine.symptom business
Zdroj:	Renal Failure. 33:298-306
ISSN:	1525-6049 0886-022X
Popis:	The effect of corticosteroids on renal cholesterol crystal embolism (CCE) remains uncertain. The aim of the present study was to elucidate the effect of steroid therapy on short- and long-term renal outcome in CCE patients.Fifty-one patients diagnosed with renal CCE were included in this retrospective study. The patients were divided into two groups according to whether or not they had received steroid therapy (steroid therapy (+), n = 32; (-), n = 19). Corticosteroids were administered at an initial dose of 10-20 mg/day after CCE diagnosis. The values of the estimated glomerular filtration rate (eGFR) in the two groups were examined at CCE diagnosis, 4 weeks after diagnosis and the last follow-up. Additionally, the % change in eGFR at 4 weeks after diagnosis and % change per year in eGFR at the last follow-up were calculated for each patient.The median values of eGFR at diagnosis in patients with and without steroid therapy were 16.4 and 17.9 mL/min/1.73 m(2), respectively. The median % change in eGFR between diagnosis and 4 weeks after diagnosis was 24% in patients with steroid therapy and 5% in those without, and this difference was statistically significant. On the other hand, there was no significant difference between the two groups in the % change in eGFR per year between diagnosis and the last follow-up.During the short period after CCE diagnosis, steroid therapy showed a good renal outcome in CCE patients. However, this treatment did not have a favorable effect on long-term renal outcome.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6c4464d42fbe29a50cee9b8b7ea248 https://doi.org/10.3109/0886022x.2011.560403 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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