Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene

Autor:	M.F. Oliver, David A. Wood, K.F. Gey, R.A. Riemersma, Cecilia C. A. Macintyre, Robert A. Elton
Rok vydání:	1991
Předmět:	Adult Male Vitamin medicine.medical_specialty medicine.medical_treatment Population Ascorbic Acid Gastroenterology Angina Pectoris Angina chemistry.chemical_compound Risk Factors Surveys and Questionnaires Internal medicine Odds Ratio medicine Humans Vitamin E Risk factor Vitamin A education education.field_of_study business.industry Smoking Carotene Retinol Confounding Factors Epidemiologic General Medicine Middle Aged medicine.disease Ascorbic acid Carotenoids Lipids Endocrinology chemistry Case-Control Studies Seasons business
Zdroj:	The Lancet. 337:1-5
ISSN:	0140-6736
DOI:	10.1016/0140-6736(91)93327-6
Popis:	The relation between risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene was examined in a population case-control study of 110 cases of angina, identified by the Chest Pain Questionnaire, and 394 controls selected from a sample of 6000 men aged 35-54. Plasma concentrations of vitamins C and E and carotene were significantly inversely related to the risk of angina. There was no significant relation with vitamin A. Smoking was a confounding factor. The inverse relation between angina and low plasma carotene disappeared and that with plasma vitamin C was substantially reduced after adjustment for smoking. Vitamin E remained independently and inversely related to the risk of angina after adjustment for age, smoking habit, blood pressure, lipids, and relative weight. The adjusted odds ratio for angina between the lowest and highest quintiles of vitamin E concentrations was 2.68 (95% confidence interval 1.07-6.70; p = 0.02). These findings suggest that some populations with a high incidence of coronary heart disease may benefit from eating diets rich in natural antioxidants, particularly vitamin E.
Databáze:	OpenAIRE
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