Identification of repositionable drugs with novel antimycotic activity by screening the Prestwick Chemical Library against emerging invasive moulds

Autor: Stéphane Ranque, Hanane Yousfi, Carole Cassagne, Fadi Bittar, Jean-Marc Rolain
Přispěvatelé: Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Microbiology (medical)
Fusarium
Antifungal Agents
030106 microbiology
Immunology
Drug repurposing
macromolecular substances
Microbiology
Chemical library
Scedosporium
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Rhizopus
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
medicine
Immunology and Allergy
[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
030212 general & internal medicine
Prestwick Chemical Library
Alexidine
Emerging fungi
ComputingMilieux_MISCELLANEOUS
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
biology
Clioquinol
Fungi
biology.organism_classification
Alternative therapeutics
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Multidrug-resistant mould
QR1-502
3. Good health
Drug repositioning
chemistry
Pharmaceutical Preparations
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Hexachlorophene
medicine.drug
Zdroj: Journal of Global Antimicrobial Resistance, Vol 21, Iss, Pp 314-317 (2020)
Journal of Global Antimicrobial Resistance
Journal of Global Antimicrobial Resistance, Elsevier, 2020, ⟨10.1016/j.jgar.2020.01.002⟩
Journal of Global Antimicrobial Resistance, 2020, ⟨10.1016/j.jgar.2020.01.002⟩
ISSN: 2213-7165
DOI: 10.1016/j.jgar.2020.01.002⟩
Popis: Objectives The incidence of severe filamentous fungal infections has increased over the past decade. Some of these filamentous fungi are resistant to available antifungals; it is thus urgent to find new compounds that are active against such life-threatening pathogens. Methods In this study, 1280 drugs (Prestwick Chemical Library) were tested against six multidrug-resistant (MDR) filamentous fungi, includingAspergillus, Fusarium, Scedosporium/Lomentospora, Rhizopus and Lichtheimia species. Results Several hits were identified that induced fungal growth inhibition ≥70%. Among the non-antifungal compounds that were effective against the clinical moulds tested in this study, clioquinol, alexidine dihydrochloride, hexachlorophene and thonzonium bromide displayed a broad activity against all strains tested. Conclusion This study enriches the potential antifungal options that can be used against MDR invasive fungal diseases.
Databáze: OpenAIRE
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