Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation
Autor: | A. T. Portman, V. Sturm, Michiel J. Staal, RP Maguire, L. Burghaus, Klaus L. Leenders, A. Koulousakis, Karl Herholz, Wolf-Dieter Heiss, Rüdiger Hilker, Jan Pruim, T. van Laar, J. Voges, B. M. de Jong |
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Přispěvatelé: | Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
Jazyk: | angličtina |
Rok vydání: | 2005 |
Předmět: |
Oncology
Male Paper medicine.medical_specialty Pathology Deep brain stimulation Parkinson's disease medicine.medical_treatment Deep Brain Stimulation METABOLISM Neuroprotection Receptors Dopamine Central nervous system disease Degenerative disease POSITRON-EMISSION-TOMOGRAPHY Subthalamic Nucleus Internal medicine medicine Humans Prospective Studies Aged ECAT EXACT business.industry Putamen Parkinson Disease Middle Aged PERFORMANCE medicine.disease F-18 DOPA-PET EVOLUTION nervous system diseases Functional imaging Psychiatry and Mental health Subthalamic nucleus Editorial Commentary SCANNER surgical procedures operative nervous system Positron-Emission Tomography Disease Progression HIGH-FREQUENCY STIMULATION Surgery Female Neurology (clinical) business FOLLOW-UP therapeutics DEEP BRAIN-STIMULATION |
Zdroj: | JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 76(9), 1217-1221. BMJ PUBLISHING GROUP |
ISSN: | 0022-3050 |
Popis: | Objectives: Glutamate mediated excitotoxicity of the hyperactive subthalamic nucleus (STN) has been reported to contribute to nigral degeneration in Parkinson's disease (PD). Deep brain stimulation of the STN (STN DBS), in its role as a highly effective treatment of severe PD motor complications, has been. thought to inhibit STN hyperactivity and therefore decrease progression of PD.Methods: In a prospective two centre study, disease progression was determined by means of serial F-18-fluorodopa (F-dopa) positron emission tomography (PET) in 30 patients with successful STN DBS over the first 16 (SD 6) months after surgery.Results: Depending on the method of PET data analysis used in the two centres, annual progression rates relative to baseline were 9.5-12.4% in the caudate and 10.7-12.9% in the putamen.Conclusions: This functional imaging study is the first to demonstrate a continuous decline of dopaminergic function in patients with advanced PD under clinically effective bilateral STN stimulation. The rates of progression in patients with STN DBS were within the range of previously reported data from longitudinal imaging studies in PD. Therefore this study could not confirm the neuroprotective properties of DBS in the STN target. |
Databáze: | OpenAIRE |
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