Participation of selected soluble cell adhesion molecules and syndecans in formation and development of endometriosis
| Autor: | Zdzisława Kondera-Anasz, Marta Smycz-Kubańska, Joanna Janusz, Aleksandra Englisz, Aleksandra Mielczarek Palacz, Aleksandra Janusz, Justyna Sikora |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Syndecans Angiogenesis media_common.quotation_subject Endometriosis Gastroenterology Young Adult Antigens CD Internal medicine parasitic diseases Follicular phase medicine Ascitic Fluid Humans Laparoscopy Menstrual cycle media_common medicine.diagnostic_test business.industry Peritoneal fluid Soluble cell adhesion molecules Obstetrics and Gynecology Middle Aged medicine.disease stomatognathic diseases Female Histopathology business Cell Adhesion Molecules |
| Zdroj: | Ginekologia Polska. 92:745-752 |
| ISSN: | 2543-6767 0017-0011 |
| DOI: | 10.5603/gp.a2021.0064 |
| Popis: | Objectives: Concentrations of soluble ICAM-2, -3, -4 and syndecan-1 and -4 have not yet been marked in the peritoneal fluid of women with endometriosis. The aim of the study was to determine whether these molecules can participate in formation and development of endometriosis. Material and methods: The study comprised of 80 women at the proliferative phase of the menstrual cycle, aged 21 to 49 years (mean age 31. 3 ± 6. 7 years) undergoing laparoscopy, to determine the causes of primary infertility and to confirm or exclude endometriosis. The study group consisted of 60 women with endometriosis in the pelvis as confirmed by laparoscopy and histopathology. The reference group consisted of 20 women in whom no endometriosis. Concentrations of selected sICAM and syndecans in the peritoneal fluid were determined with the use of ELISA method. Results: Decreased concentrations of sICAM-2 and increased concentrations of sICAM-3, sICAM-4 and syndnecan-1 and -4 were observed in the peritoneal fluid of women with endometriosis and compared with concentrations of this parameter in the reference group (p < 0.0001). Additionally, negative correlation was found between the concentrations of sICAM-3 and sICAM-2 among women with endometriosis. There was no statistically significant correlation between the concentration of sICAM-2 and sICAM-4, sICAM-3 and sICAM-4 and syndecan-1 and syndecan-4 in the examined women. Conclusions: Changes in concentrations of all the evaluated molecules were observed in the peritoneal fluid in women suffering from endometriosis. Since they have a role in regulation of the immune response, in angiogenesis and apoptosis of the endometrial cells. |
| Databáze: | OpenAIRE |
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