A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions

Autor:	Massimiliano Massi, Ivan Greguric, Bo Zhang, Mitchell A. Klenner, Janice R. Aldrich-Wright, Adam J. Guastella, Tiffany R. Sia, Lawson K. Spare, Giancarlo Pascali, Benjamin H. Fraser, Anwen M. Krause-Heuer
Rok vydání:	2017
Předmět:	010405 organic chemistry Organic Chemistry Inorganic chemistry chemistry.chemical_element General Chemistry Rhenium 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Adsorption chemistry Azeotropic distillation Scientific method Anhydrous Fluorine
Zdroj:	Chemistry (Weinheim an der Bergstrasse, Germany). 23(27)
ISSN:	1521-3765
Popis:	Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b64110a7656e5017e8d1a7d351db383 https://pubmed.ncbi.nlm.nih.gov/28332244 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.