STIMULATORY EFFECT OF THE DOPA-DECARBOXYLASE INHIBITOR Ro 4-4602 ON PROLACTIN RELEASE; INHIBITION BY L-DOPA, METERGOLINE, METHYSERGIDE AND 2-Br-α-ERGOCRYPTINE
| Autor: | Guido Pozza, E. Castegnaro, M. P. Vettaro, Giancarlo Viberti, Antonio E. Pontiroli |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Male endocrine system Metergoline medicine.medical_specialty Time Factors Adolescent Endocrinology Diabetes and Metabolism Methysergide Administration Oral Levodopa Benserazide chemistry.chemical_compound Endocrinology Pituitary Gland Anterior Internal medicine medicine Humans Drug Interactions Ergolines Bromocriptine Clinical Trials as Topic Aromatic L-amino acid decarboxylase General Medicine Middle Aged 2-Br-alpha-ergocryptine Stimulation Chemical Prolactin Hydrazines chemistry Pituitary Gland Female Secretory Rate hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Acta Endocrinologica. 84:36-44 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0840036 |
| Popis: | In order to evaluate the role of serotonin (5-HT) in the effect of L-dopa on prolactin (PRL) release, normal subjects received L-dopa alone or L-dopa plus a dopa-decarboxylase inhibitor (Ro 4-4602) in basal conditions and following the repeated administration of metergoline, a specific anti-5-HT agent. The inhibiting effect of L-dopa on PRL levels was enhanced by metergoline. On the contrary, L-dopa plus Ro 4-4602 induced a sharp increase in serum PRL levels. This effect was completely abolished by metergoline, which also significantly reduced fasting PRL levels in all the subjects studied. Ro 4-4602 alone induced a significant increase in serum PRL levels, similar to that commonly observed with chlorpromazine and TRH. The effect was similar in males and in females and was reproducible in experiments performed on different days. The effect of Ro 4-4602 was completely abolished by 2-Br-α-ergocryptine and metergoline, and, to a lesser degree, was reduced by methysergide. These results suggest that Ro 4-4602 is a reliable stimulus to PRL release and show that any stimulus to PRL secretion may be blocked by both dopa-minergic and anti-serotonin agents. |
| Databáze: | OpenAIRE |
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