Flexible biodegradable citrate-based polymeric step-index optical fiber
| Autor: | Nikhil Mehta, Dingying Shan, Surge Kalaba, Gloria B. Kim, Zhiwen Liu, Chenji Zhang, Jian Yang |
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| Rok vydání: | 2017 |
| Předmět: |
Scaffold
Materials science Fabrication Optical fiber Polymers Biophysics Biocompatible Materials Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry Elastomer 01 natural sciences Citric Acid Article law.invention Rats Sprague-Dawley Biomaterials law Materials Testing Animals Fiber Optic Technology Fiber Optical Fibers chemistry.chemical_classification Optical Imaging Equipment Design Prostheses and Implants Polymer 021001 nanoscience & nanotechnology Biodegradable polymer 0104 chemical sciences Refractometry Elastomers chemistry Mechanics of Materials Ceramics and Composites 0210 nano-technology Refractive index Biomedical engineering |
| Zdroj: | Biomaterials. 143:142-148 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2017.08.003 |
| Popis: | Implanting fiber optical waveguides into tissue or organs for light delivery and collection is among the most effective ways to overcome the issue of tissue turbidity, a long-standing obstacle for biomedical optical technologies. Here, we report a citrate-based material platform with engineerable opto-mechano-biological properties and demonstrate a new type of biodegradable, biocompatible, and low-loss step-index optical fiber for organ-scale light delivery and collection. By leveraging the rich designability and processibility of citrate-based biodegradable polymers, two exemplary biodegradable elastomers with a fine refractive index difference and yet matched mechanical properties and biodegradation profiles were developed. Furthermore, we developed a two-step fabrication method to fabricate flexible and low-loss (0.4 db/cm) optical fibers, and performed systematic characterizations to study optical, spectroscopic, mechanical, and biodegradable properties. In addition, we demonstrated the proof of concept of image transmission through the citrate-based polymeric optical fibers and conducted in vivo deep tissue light delivery and fluorescence sensing in a Sprague-Dawley (SD) rat, laying the groundwork for realizing future implantable devices for long-term implantation where deep-tissue light delivery, sensing and imaging are desired, such as cell, tissue, and scaffold imaging in regenerative medicine and in vivo optogenetic stimulation. |
| Databáze: | OpenAIRE |
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