Health effects after inhalation of micro- and nano-sized zinc oxide particles in human volunteers

Autor: Christoph Edzard Seifert, Thomas Brüning, Jürgen Bünger, Benjamin Kendzia, Christian Monsé, Rolf Merget, Götz A. Westphal, Vera van Kampen, E. Marek, Nina Rosenkranz, Monika Raulf, Leonie Schürmeyer, Birger Jettkant
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Time Factors
Neutrophils
Health
Toxicology and Mutagenesis
Respiratory System
Nanoparticle
Metal Nanoparticles
010501 environmental sciences
Toxicology
Human inhalation study
01 natural sciences
Micro-sized particles
Monocytes
Random Allocation
0302 clinical medicine
Inorganic Compounds
Inhalation
Chemistry
General Medicine
030210 environmental & occupational health
Deposition (aerosol physics)
medicine.anatomical_structure
Female
Inflammation Mediators
Body Temperature Regulation
Adult
chemistry.chemical_element
Zinc
03 medical and health sciences
Young Adult
Double-Blind Method
Zinc oxide
Administration
Inhalation
medicine
Humans
ddc:610
Particle Size
Nano sized
0105 earth and related environmental sciences
Nebulizers and Vaporizers
Sputum
medicine.disease
Deposition efficiency
Bicycling
Particle
Nanoparticles
Metal fume fever
Biomarkers
Respiratory tract
Nuclear chemistry
Acute-Phase Proteins
Zdroj: Archives of Toxicology
ISSN: 1432-0738
0340-5761
Popis: Inhalation of ZnO particles can cause inflammation of the airways and metal fume fever. It is unclear if different sizes of the particles alter these effects. However, various studies report higher biological activity of other nano-sized particles compared to microparticles. No effects at all were observed after inhalation of micro- and nano-sized zinc oxide (ZnO) particle concentrations of 0.5 mg/m3. Studies with different particle sizes of ZnO at higher exposures are not available. Accordingly, we hypothesized that inhalation of nano-sized ZnO particles induces stronger health effects than the inhalation of the same airborne mass concentration of micro-sized ZnO particles. 16 healthy volunteers (eight men, eight women) were exposed to filtered air and ZnO particles (2.0 mg/m3) for 2 h (one session with nano- and one with micro-sized ZnO) including 1 h of cycling at moderate workload. Effect parameters were symptoms, body temperature, inflammatory markers in blood and in induced sputum. Induced sputum was obtained at baseline examination, 22 h after exposure and at the end of the final test. The effects were assessed before, immediately after, about 22 h after, as well as two and three days after each exposure. Neutrophils, monocytes and acute-phase proteins in blood increased 22 h after micro- and nano-sized ZnO exposure. Effects were generally stronger with micro-sized ZnO particles. Parameters in induced sputum showed partial increases on the next day, but the effect strengths were not clearly attributable to particle sizes. The hypothesis that nano-sized ZnO particles induce stronger health effects than micro-sized ZnO particles was not supported by our data. The stronger systemic inflammatory responses after inhalation of micro-sized ZnO particles can be explained by the higher deposition efficiency of micro-sized ZnO particles in the respiratory tract and a substance-specific mode of action, most likely caused by the formation of zinc ions. Electronic supplementary material The online version of this article (10.1007/s00204-020-02923-y) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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