| Autor: |
Marc, Kermorgant, Marc, Labrunée, Fabien, Despas, Ophélie, Hélissen, Thomas, Geeraerts, Elisabeth, Lambert, Eric, Schmidt, Jean-Michel, Senard, Dina N, Arvanitis, Nathalie, Nasr, Anne Pavy-Le, Traon |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Autonomic Neuroscience. 243:103036 |
| ISSN: |
1566-0702 |
| DOI: |
10.1016/j.autneu.2022.103036 |
| Popis: |
Acute head-down-tilt (HDT) simulates short duration hemodynamic impact of microgravity. We sought to determine whether an increase in ICP caused by acute HDT affects sympathetic nervous system activity and cerebral blood flow velocities (CBFV) in healthy male volunteers.HDT protocol was established as follows: basal condition immediately followed by gradual negative angles (-10°, -20° and -30°) lasting 10mn and then a return to basal condition. Velocities in the MCA (CBFV) were monitored using TCD. Sympathetic activity was assessed using MSNA. Baroreflex sensitivity (BRS) was measured using the sequence method. ICP changes were assessed using ultrasonography of the optic nerve sheath diameter (ONSD). Cerebral autoregulation (CA) was evaluated by transfer function and the autoregulatory index (Mxa).Twelve male volunteers (age: 35 ± 2 years) were included. Neither blood pressure nor heart rate was significantly modified during HDT. ONSD increased significantly at each step of HDT and remained elevated during Recovery. MSNA burst incidence increased at -30°. A positive correlation between variations in ONSD and variations in MSNA burst incidence was observed at -20°. CBFV were significantly diminished at -20° and -30. In the LF band, the transfer function coherence was reduced at -30° and the transfer function phase was increased at -30° and during Recovery.We found that an acute though modest increase in ICP induced by HDT was associated with an increase of sympathetic activity as assessed by MSNA, and with a reduction of CBFV with preserved CA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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