Pre-clinical evaluation of novel mucoadhesive bilayer patches for local delivery of clobetasol-17-propionate to the oral mucosa
| Autor: | Paul V. Hatton, L. Siim Madsen, Jens C. Hansen, Craig Murdoch, Helen E. Colley, Sarah R. Baker, Katy D'Apice, Martin E. Santocildes-Romero, Z. Said, Martin H. Thornhill |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
Time Factors Swine Bioadhesive media_common.quotation_subject Biophysics Adhesion (medicine) Bioengineering 02 engineering and technology Pharmacology Recurrent aphthous stomatitis Biomaterials Lesion 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Adhesives Medicine Animals Humans Oral mucosa media_common Clobetasol Cell Death business.industry Mouth Mucosa 021001 nanoscience & nanotechnology medicine.disease Rats stomatognathic diseases Mucus medicine.anatomical_structure Targeted drug delivery Mechanics of Materials 030220 oncology & carcinogenesis Ceramics and Composites Oral lichen planus medicine.symptom 0210 nano-technology business |
| Zdroj: | Biomaterials. 178 |
| ISSN: | 1878-5905 |
| Popis: | Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are chronic inflammatory conditions often characterised by erosive and/or painful oral lesions that have a considerable impact on quality of life. Current treatment often necessitates the use of steroids in the form of mouthwashes, creams or ointments, but these are often ineffective due to inadequate drug contact times with the lesion. Here we evaluate the performance of novel mucoadhesive patches for targeted drug delivery. Electrospun polymeric mucoadhesive patches were produced and characterised for their physical properties and cytotoxicity before evaluation of residence time and acceptability in a human feasibility study. Clobetasol-17-propionate incorporated into the patches was released in a sustained manner in both tissue-engineered oral mucosa and ex vivo porcine mucosa. Clobetasol-17 propionate-loaded patches were further evaluated for residence time and drug release in an in vivo animal model and demonstrated prolonged adhesion and drug release at therapeutic-relevant doses and time points. These data show that electrospun patches are adherent to mucosal tissue without causing tissue damage, and can be successfully loaded with and release clinically active drugs. These patches hold great promise for the treatment of oral conditions such as OLP and RAS, and potentially many other oral lesions. |
| Databáze: | OpenAIRE |
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