Unusual fusion between ventral and dorsal primordia causes anomalous pancreaticobiliary junction
| Autor: | Bunsei Nobukawa, Hiroyuki Tadokoro, Masaru Takase |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Common Bile Duct Diseases Biology Pancreatic Polypeptide Pathology and Forensic Medicine Immunoenzyme Techniques Fatal Outcome Sphincter of Oddi medicine Humans Pancreatic polypeptide Primordium Gallbladder cancer Pancreas Aged Common Bile Duct Pancreatic duct Common bile duct Pancreatic Ducts General Medicine Anatomy medicine.disease medicine.anatomical_structure Embryology Female Gallbladder Neoplasms Biomarkers |
| Zdroj: | Pathology International. 58:498-502 |
| ISSN: | 1440-1827 1320-5463 |
| DOI: | 10.1111/j.1440-1827.2008.02263.x |
| Popis: | Anomalous pancreaticobiliary junction (APBJ) is a congenital anomaly in which the pancreatic duct joins the common bile duct proximal to the sphincter of Oddi. Anatomical and immunohistochemical examination of the pancreas with APBJ has rarely been performed. A 72-year-old woman with gallbladder cancer and APBJ died of respiratory failure. Macroscopic features of the pancreas were examined in detail. Immunohistochemistry using anti-pancreatic polypeptide (anti-PP) antibody was done to discriminate ventral and dorsal pancreas. Macroscopically the inferior part of the head of the pancreas was smaller than normal. The posterior surface of the head was obliquely grooved. Part of the pancreatic head protruded into the posterior side of the pancreatic head. A PP-rich region was located in the superioposterior position of the pancreas head. Considering the relationship between the ventral and dorsal pancreas, it was inferred that the ventral primordium could obliquely fuse with the dorsal primordium during embryological development. As a result, APBJ occurs through an abnormal fusion between ventral and dorsal primordia. |
| Databáze: | OpenAIRE |
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