Discovery of novel inhibitors targeting movement protein for controlling the transmission of banana bunchy top virus infection in plantain by structure-based virtual screening
| Autor: | Bharathi Nathan, Srividhya Vellingiri, Subashini Swaminathan, Kalpana Raja, Archana Prabahar, Ramalingam Jegadeesan |
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| Rok vydání: | 2018 |
| Předmět: |
Virtual screening
biology Transmission (medicine) Clinical Biochemistry Biomedical Engineering food and beverages Small Molecule Libraries Health Informatics biology.organism_classification Virology Banana bunchy top virus Health Information Management Structure based Viral disease Movement protein Pathogen |
| Zdroj: | International Journal of Bioinformatics Research and Applications. 14:305 |
| ISSN: | 1744-5493 1744-5485 |
| Popis: | Banana bunchy top virus (BBTV), the pathogen causing banana bunchy top disease (BBTD) belongs to the genus Babuvirus of the family Nanoviridae and produces significant yield loss. BBTD is the most destructive viral diseases affecting bananas worldwide causing infections that result in bunched leaves, stunted and fruitless plants. So far, there are no effective control measures for controlling and preventing this viral disease. The amino terminal region of the movement protein is responsible for cell-to-cell movement. The present study aims at inhibiting this target region by discovering novel inhibitors through virtual screening of small molecule libraries coupled with post-docking analysis of most potent inhibitors. Our study based on virtual screening of small molecule datasets determined 10 most potential inhibitors to be considered as lead compounds in controlling the spread of BBTV infection in plantain. |
| Databáze: | OpenAIRE |
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