Effect of testosterone replacement therapy on bone mineral density in patients with Klinefelter syndrome
| Autor: | Young Min Joo, Hyo Serk Lee, Ju Tae Seo, Dae Gi Jo |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Globulin Hormone Replacement Therapy Endocrinology & Metabolism Sex hormone-binding globulin Klinefelter Syndrome Bone Density Internal medicine medicine Bone mineral density Humans Testosterone Femoral neck Bone mineral Hematology biology business.industry General Medicine medicine.disease Prostate-specific antigen Endocrinology medicine.anatomical_structure testosterone biology.protein Female Original Article Klinefelter syndrome business |
| Zdroj: | Yonsei Medical Journal |
| ISSN: | 1976-2437 |
| Popis: | PURPOSE Klinefelter syndrome (KS) is related to testicular insufficiency, which causes low testosterone levels in serum. Generally, sex hormone levels and bone mineral density (BMD) are lower in patients with KS than normal. We investigated the effects of testosterone replacement on serum testosterone levels and BMD in KS patients. MATERIALS AND METHODS From December 2005 to March 2008, 18 KS patients with a 47, XXY karyotype were treated with initial intramuscular injections of long-acting testosterone undecanoate (Nebido®, 1000 mg/4 mL) at baseline and second injections after six weeks. An additional four injections were administered at intervals of 12 weeks after the second injection. BMD was measured at the lumbar spine (L2-4), the left femoral neck and Ward's triangle, using dual energy X-ray absorptiometry. Medical histories, physical examinations and prostate specific antigen, hematology and serum chemistry were conducted for each patient. In addition, total testosterone and sex hormone-binding globulin levels were measured. RESULTS Following testosterone replacement, mean serum total testosterone increased significantly from baseline (0.90 vs. 4.51 ng/mL, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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