Sensorimotor hallucinations in Parkinson’s disease
| Autor: | Fred Sampedro, Helena Bejr-Kasem, Masayuki Hara, J. Ghika, Fosco Bernasconi, Paul Krack, Pierre R. Burkhard, Jevita Potheegadoo, Stéphanie Konik, Giedre Stripeikyte, Matteo Franza, Javier Pagonabarraga, Michel Akselrod, Judit Horvath, Matthieu Bereau, Giulio Rognini, Olaf Blanke, Dimitri Van De Ville, Michela Bassolino, Saul Martinez-Horta, Eva Blondiaux, Nathan Faivre, Jaime Kulisevsky |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Psychosis medicine.medical_specialty Parkinson's disease business.industry Disease Audiology medicine.disease Lesion 03 medical and health sciences 0302 clinical medicine Medicine Dementia Risk factor Cognitive decline medicine.symptom business Pathological 030217 neurology & neurosurgery 030304 developmental biology |
| Popis: | SummaryHallucinations in Parkinson’s disease (PD) are one of the most disturbing non-motor symptoms, affect half of the patients, and constitute a major risk factor for adverse clinical outcomes such as psychosis and dementia. Here we report a robotics-based approach, enabling the induction of a specific clinically-relevant hallucination (presence hallucination, PH) under controlled experimental conditions and the characterization of a PD subgroup with enhanced sensorimotor sensitivity for such robot-induced PH. Using MR-compatible robotics in healthy participants and lesion network mapping analysis in neurological non-PD patients, we identify a fronto-temporal network that was associated with PH. This common PH-network was selectively disrupted in a new and independent sample of PD patients and predicted the presence of symptomatic PH. These robotics-neuroimaging findings determine the behavioral and neural mechanisms of PH and reveal pathological cortical sensorimotor processes of PH in PD, identifying a more severe form of PD associated with psychosis and cognitive decline. |
| Databáze: | OpenAIRE |
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